Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propafenone
Drug ID BADD_D01856
Description An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Indications and Usage Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.
Marketing Status Prescription; Discontinued
ATC Code C01BC03
DrugBank ID DB01182
KEGG ID D08435
MeSH ID D011405
PubChem ID 4932
TTD Drug ID D0J2KV
NDC Product Code 51407-477; 51407-479; 24979-087; 71205-940; 12598-6285; 51407-478; 24979-085; 69680-130; 71205-941; 69680-132; 69680-131; 71205-942; 24979-086
Synonyms Propafenone | Propafenone Hydrochloride, (R)-Isomer | Rytmo-Puren | Rytmogenat | SA-79 | SA 79 | SA79 | Propafenone, (+-)-Isomer | Propafenone, (R)-Isomer | Propafenone, (S)-Isomer | Propamerck | Apo-Propafenone | Baxarytmon | Cuxafenon | Fenoprain | Jutanorm | Nistaken | Prolecofen | Propafenon AL | Propafenon Hexal | Propafenone Hydrochloride | Hydrochloride, Propafenone | Propafenone Hydrochloride, (S)-Isomer | Rythmol | Propafenon Minden | Norfenon | Pintoform | Rytmonorm | Arythmol
Chemical Information
Molecular Formula C21H27NO3
CAS Registry Number 54063-53-5
SMILES CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cholestasis09.01.01.0010.004790%Not Available
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Circulatory collapse24.06.02.0010.000500%Not Available
Collagen-vascular disease15.06.01.004; 10.04.04.001--Not Available
Coma17.02.09.0010.003832%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.003748%Not Available
Conduction disorder02.03.01.0080.003832%
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.0010.003832%
Coronary artery disease02.02.01.001; 24.04.04.006--Not Available
Costochondritis15.07.03.001--Not Available
Cough22.02.03.001--
Cyanosis22.02.02.007; 02.01.02.002; 24.03.01.0070.003832%
Deafness04.02.01.001--Not Available
Death08.04.01.001--
Defect conduction intraventricular02.03.01.018--Not Available
Dehydration14.05.05.001--
Dementia19.20.02.001; 17.03.01.001--Not Available
Depressed level of consciousness17.02.04.0020.003832%
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 02.01.02.004; 17.02.05.0030.008621%
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Dry throat22.02.05.004; 07.06.01.005--Not Available
Duodenitis07.08.03.001--Not Available
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