Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Promethazine hydrochloride
Drug ID BADD_D01855
Description Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946.[A189901] Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A190153,A190159,A190150,A190171] Promethazine was granted FDA approval before 29 March 1951.[A190177,L4000]
Indications and Usage For the treatment of allergic disorders, and nausea/vomiting.
Marketing Status Prescription; Discontinued
ATC Code D04AA10; R06AD02
DrugBank ID DB01069
KEGG ID D00480
MeSH ID D011398
PubChem ID 6014
TTD Drug ID D0T2XU
NDC Product Code 53002-4020; 0641-1496; 68001-162; 70518-0165; 0641-0955; 52584-495; 71335-0012; 58118-5307; 0641-0948; 45865-592; 0641-0956; 67296-0564; 55154-8080; 50090-4603; 48581-114; 0641-1495; 50090-2986; 71872-7285; 60429-149; 50090-4750; 63629-8446; 55700-221; 63629-1591; 0713-0526; 61919-047; 51927-9018; 0713-0536; 43063-874; 52584-078; 70752-138; 71335-0989; 65841-041; 72189-176; 43063-447; 0641-6085; 50383-801; 50090-3894; 50396-7517; 55700-690; 51672-5296; 68071-4737; 70518-2481; 68071-4865; 55154-2861; 63629-9151; 50090-4813; 45802-759; 63629-8445; 0904-6461; 0121-0927; 50090-3897; 71335-1139; 49452-6087; 53002-4021; 42708-119; 64380-794; 65162-521; 68382-042; 65841-146; 0641-0929; 60432-608; 68788-8162; 63739-213; 70518-2896; 54154-011; 63187-038; 50090-4124; 60429-151; 0641-6082; 0641-0928; 0641-6208; 0404-9942; 0641-0949; 60760-456; 0591-5319; 10702-004; 0615-8154; 68071-4514; 68001-163; 70518-3340; 55579-401; 60760-830; 43063-875; 65841-042; 63629-1742; 70518-2656; 10135-495; 51672-5297; 71872-7077; 27808-051; 70518-0141; 50090-4875; 0641-6084; 0641-6083; 55579-402; 61919-191; 43063-405; 10702-003; 65162-745; 65162-522; 39822-5525; 63187-858; 69988-0022; 0713-0132; 67296-0198; 64380-793; 0781-1832; 39822-5550; 68084-154; 68071-4686; 68071-4424; 43063-876; 65841-040; 68071-4544; 10702-002; 70518-1306; 50090-4453; 68788-7886; 50090-0879; 68084-155; 71335-1359; 71205-126; 55289-928; 0781-1830; 0591-5307; 17856-0608; 0404-9941; 50090-4811; 38779-0253; 50090-4608; 82298-902; 50090-4812; 50090-5362; 51552-0147; 52584-496; 70518-2488; 68001-161; 63187-829; 60429-150; 64380-792; 70518-0519; 68382-040; 50090-3588; 45802-758; 68071-4809; 0404-9940; 63629-7670; 68382-041; 67296-1120; 70408-146; 61919-228; 43063-060; 57451-1205; 67296-0086
Synonyms Promethazine | Prometazin | Proazamine | Rumergan | Diprazin | Isopromethazine | Phenergan | Phenargan | Phensedyl | Pipolfen | Pipolphen | Promet | Promethazine Hydrochloride | Hydrochloride, Promethazine | Prothazin | Pyrethia | Remsed | Atosil | Diphergan
Chemical Information
Molecular Formula C17H20N2S.ClH
CAS Registry Number 58-33-3
SMILES CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nightmare19.02.03.003--Not Available
Oculogyric crisis17.01.03.002; 06.05.02.002--Not Available
Photosensitivity reaction23.03.09.003--
Protrusion tongue07.14.02.002; 17.02.05.037--Not Available
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Sedation17.02.04.005--Not Available
Seizure17.12.03.001--
Somnolence19.02.05.003; 17.02.04.006--
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombocytopenic purpura23.06.01.007; 01.08.01.003--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Torticollis17.01.03.003; 15.05.04.003--Not Available
Tremor17.01.06.002--
Urticaria10.01.06.001; 23.04.02.001--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
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