Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Promethazine hydrochloride
Drug ID BADD_D01855
Description Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946.[A189901] Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A190153,A190159,A190150,A190171] Promethazine was granted FDA approval before 29 March 1951.[A190177,L4000]
Indications and Usage For the treatment of allergic disorders, and nausea/vomiting.
Marketing Status Prescription; Discontinued
ATC Code D04AA10; R06AD02
DrugBank ID DB01069
KEGG ID D00480
MeSH ID D011398
PubChem ID 6014
TTD Drug ID D0T2XU
NDC Product Code 53002-4020; 0641-1496; 68001-162; 70518-0165; 0641-0955; 52584-495; 71335-0012; 58118-5307; 0641-0948; 45865-592; 0641-0956; 67296-0564; 55154-8080; 50090-4603; 48581-114; 0641-1495; 50090-2986; 71872-7285; 60429-149; 50090-4750; 63629-8446; 55700-221; 63629-1591; 0713-0526; 61919-047; 51927-9018; 0713-0536; 43063-874; 52584-078; 70752-138; 71335-0989; 65841-041; 72189-176; 43063-447; 0641-6085; 50383-801; 50090-3894; 50396-7517; 55700-690; 51672-5296; 68071-4737; 70518-2481; 68071-4865; 55154-2861; 63629-9151; 50090-4813; 45802-759; 63629-8445; 0904-6461; 0121-0927; 50090-3897; 71335-1139; 49452-6087; 53002-4021; 42708-119; 64380-794; 65162-521; 68382-042; 65841-146; 0641-0929; 60432-608; 68788-8162; 63739-213; 70518-2896; 54154-011; 63187-038; 50090-4124; 60429-151; 0641-6082; 0641-0928; 0641-6208; 0404-9942; 0641-0949; 60760-456; 0591-5319; 10702-004; 0615-8154; 68071-4514; 68001-163; 70518-3340; 55579-401; 60760-830; 43063-875; 65841-042; 63629-1742; 70518-2656; 10135-495; 51672-5297; 71872-7077; 27808-051; 70518-0141; 50090-4875; 0641-6084; 0641-6083; 55579-402; 61919-191; 43063-405; 10702-003; 65162-745; 65162-522; 39822-5525; 63187-858; 69988-0022; 0713-0132; 67296-0198; 64380-793; 0781-1832; 39822-5550; 68084-154; 68071-4686; 68071-4424; 43063-876; 65841-040; 68071-4544; 10702-002; 70518-1306; 50090-4453; 68788-7886; 50090-0879; 68084-155; 71335-1359; 71205-126; 55289-928; 0781-1830; 0591-5307; 17856-0608; 0404-9941; 50090-4811; 38779-0253; 50090-4608; 82298-902; 50090-4812; 50090-5362; 51552-0147; 52584-496; 70518-2488; 68001-161; 63187-829; 60429-150; 64380-792; 70518-0519; 68382-040; 50090-3588; 45802-758; 68071-4809; 0404-9940; 63629-7670; 68382-041; 67296-1120; 70408-146; 61919-228; 43063-060; 57451-1205; 67296-0086
Synonyms Promethazine | Prometazin | Proazamine | Rumergan | Diprazin | Isopromethazine | Phenergan | Phenargan | Phensedyl | Pipolfen | Pipolphen | Promet | Promethazine Hydrochloride | Hydrochloride, Promethazine | Prothazin | Pyrethia | Remsed | Atosil | Diphergan
Chemical Information
Molecular Formula C17H20N2S.ClH
CAS Registry Number 58-33-3
SMILES CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Apnoea22.02.01.001--
Asthma10.01.03.010; 22.03.01.002--Not Available
Blood pressure decreased13.14.03.002--Not Available
Blood pressure increased13.14.03.005--Not Available
Bradycardia02.03.02.002--Not Available
Catatonia19.11.01.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conversion disorder19.24.01.001--Not Available
Coordination abnormal17.02.02.004--Not Available
Delirium19.13.02.001--
Dermatitis23.03.04.002--Not Available
Diplopia17.17.01.005; 06.02.06.002--Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Dry mouth07.06.01.002--
Dyskinesia17.01.02.006--
Euphoric mood19.04.02.006--
Extrapyramidal disorder17.01.02.007--
Fatigue08.01.01.002--
Hallucination19.10.02.002--
Insomnia19.02.01.002; 17.15.03.002--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Leukopenia01.02.02.001--Not Available
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Neuroleptic malignant syndrome08.05.01.005; 17.05.02.003; 15.05.04.015; 12.03.01.003--Not Available
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