Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Promethazine
Drug ID BADD_D01854
Description Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946.[A189901] Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A190153,A190159,A190150,A190171] Promethazine was granted FDA approval before 29 March 1951.[A190177,L4000]
Indications and Usage For the treatment of allergic disorders, and nausea/vomiting.
Marketing Status Prescription; Discontinued
ATC Code D04AA10; R06AD02
DrugBank ID DB01069
KEGG ID D00494
MeSH ID D011398
PubChem ID 4927
TTD Drug ID D0T2XU
NDC Product Code 65162-678; 54348-117
Synonyms Promethazine | Prometazin | Proazamine | Rumergan | Diprazin | Isopromethazine | Phenergan | Phenargan | Phensedyl | Pipolfen | Pipolphen | Promet | Promethazine Hydrochloride | Hydrochloride, Promethazine | Prothazin | Pyrethia | Remsed | Atosil | Diphergan
Chemical Information
Molecular Formula C17H20N2S
CAS Registry Number 60-87-7
SMILES CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Muscle twitching15.05.03.0050.009746%Not Available
Mydriasis17.02.11.003; 06.05.03.0040.018100%Not Available
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Necrosis24.04.02.006; 08.03.03.0010.000726%Not Available
Nervousness19.06.02.003--Not Available
Neuroleptic malignant syndrome17.05.02.003; 15.05.04.015; 12.03.01.003; 08.05.01.0050.005569%Not Available
Nightmare19.02.03.0030.002785%Not Available
Nystagmus06.05.02.006; 17.02.02.0060.004177%
Oculogyric crisis17.01.03.002; 06.05.02.002--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Opisthotonus17.01.03.0050.002785%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.0100.006962%
Pallor24.03.04.001; 23.03.03.031; 08.01.03.0320.005569%Not Available
Palpitations02.01.02.003--
Paraesthesia17.02.06.0050.008354%
Paralysis17.01.04.0040.008354%Not Available
Paranoia19.05.01.0050.002785%Not Available
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.0160.002785%Not Available
Phlebitis24.05.03.001; 12.02.01.002--
Photophobia06.01.01.004; 17.17.02.0060.002785%
Photosensitivity reaction23.03.09.003--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Premature baby18.04.02.0010.004177%Not Available
Protrusion tongue17.02.05.037; 07.14.02.002--Not Available
Pruritus23.03.12.0010.009746%
Psychomotor hyperactivity19.11.02.003; 17.01.02.0110.002785%Not Available
Pulmonary embolism24.01.06.001; 22.06.02.0010.008354%Not Available
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