Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Proguanil
Drug ID BADD_D01853
Description Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, _Plasmodium falciparum_ and _Plasmodium vivax_, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
Indications and Usage For the causal prevention and suppression of malaria caused by susceptible strains of P. falciparum and other species of Plasmodium found in some geographical areas of the world.
Marketing Status Not Available
ATC Code P01BB01
DrugBank ID DB01131
KEGG ID D08428
MeSH ID D002727
PubChem ID 6178111
TTD Drug ID D0P8RS
NDC Product Code 65977-0071
Synonyms Proguanil | Chlorguanid | Chloroguanide | Proguanil Hydrochloride | Hydrochloride, Proguanil | Chloroguanide Hydrochloride | Hydrochloride, Chloroguanide | Paludrine | Paludrin | Bigumal | Chloriguane
Chemical Information
Molecular Formula C11H16ClN5
CAS Registry Number 500-92-5
SMILES CC(C)N=C(N)N=C(N)NC1=CC=C(C=C1)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Amylase increased13.05.01.009--
Body temperature increased13.15.01.001--Not Available
Cough22.02.03.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Erythema23.03.06.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Hallucination19.10.02.002--
Headache17.14.01.001--
Immune system disorder10.02.01.001--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Pancytopenia01.03.03.003--Not Available
Rash23.03.13.001--Not Available
Skin disorder23.03.03.007--Not Available
Stomatitis07.05.06.005--
Vomiting07.01.07.003--
Lymphatic disorder01.09.01.003--Not Available
Hepatic enzyme increased13.03.01.019--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Blood disorder01.05.01.004--Not Available
Hepatobiliary disease09.01.08.003--Not Available
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