Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Procarbazine
Drug ID BADD_D01846
Description An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
Indications and Usage For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
Marketing Status approved; investigational
ATC Code L01XB01
DrugBank ID DB01168
KEGG ID D08423
MeSH ID D011344
PubChem ID 4915
TTD Drug ID D08GYO
NDC Product Code Not Available
UNII 35S93Y190K
Synonyms Procarbazine | Procarbazine Monohydrobromide | Monohydrobromide, Procarbazine | Procarbazine Hydrochloride | Hydrochloride, Procarbazine | Procarbazine Monohydrochloride | Monohydrochloride, Procarbazine | Matulane | Natulan
Chemical Information
Molecular Formula C12H19N3O
CAS Registry Number 671-16-9
SMILES CC(C)NC(=O)C1=CC=C(C=C1)CNNC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.0030.000246%Not Available
Papilloedema24.03.07.001; 17.07.02.004; 06.09.02.002--
Paraesthesia23.03.03.094; 17.02.06.005--
Pericarditis02.06.02.001--
Peroneal nerve palsy17.09.02.003--Not Available
Petechiae01.01.03.002; 24.07.06.004; 23.06.01.003--Not Available
Photophobia17.17.02.006; 06.01.01.004--
Photosensitivity reaction23.03.09.003--
Pleural effusion22.05.02.002--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Poikilocytosis01.07.02.009--Not Available
Pollakiuria20.02.02.007--
Pruritus23.03.12.001--
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Pyrexia08.05.02.0030.000828%
Rash23.03.13.0010.006089%Not Available
Raynaud's phenomenon24.04.03.003--Not Available
Retinal haemorrhage24.07.05.003; 06.10.01.001--Not Available
Rhinorrhoea22.12.03.0210.000381%
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Skin discolouration23.03.03.0050.000381%Not Available
Skin hyperpigmentation23.05.01.003--
Sleep disorder19.02.04.0010.000381%Not Available
Somnolence19.02.05.003; 17.02.04.006--
Speech disorder22.12.03.027; 19.19.02.002; 17.02.08.0030.000381%Not Available
Stomatitis07.05.06.0050.000571%
Syncope17.02.04.008; 02.11.04.015; 24.06.02.012--
Tachycardia02.03.02.007--Not Available
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