Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Prazosin hydrochloride
Drug ID BADD_D01828
Description Prazosin, also known as _Minipress_, is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988 [L5828]. It belongs to the class of drugs known as alpha-1 antagonists [FDA label], [A176630]. Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTSD) and associated nightmares [A176618, A176621, A176624].
Indications and Usage For treatment of hypertension, symptomatic benign prostatic hyperplasia, and severe congestive heart failure. May also be used alone or in combination with β-blockers in the preoperative management of signs and symptoms of pheochromocytoma.
Marketing Status Prescription; Discontinued
ATC Code C02CA01
DrugBank ID DB00457
KEGG ID D00609
MeSH ID D011224
PubChem ID 68546
TTD Drug ID D0WV3U
NDC Product Code 50090-5512; 51079-632; 70518-3375; 0069-4310; 0904-7021; 71610-571; 62207-974; 68788-7335; 71335-1556; 70518-1895; 58159-043; 50923-0462; 62559-582; 0093-4067; 43063-248; 0378-2302; 0069-4270; 60429-973; 71335-1932; 55154-8181; 43063-260; 70518-3352; 70010-086; 50090-5695; 70518-2178; 68788-8144; 0904-7022; 0069-4380; 70518-1884; 0069-4370; 0378-3205; 0378-1101; 60715-0011; 63629-8325; 51079-631; 50379-0019; 68084-997; 55289-536; 63629-6873; 70518-2177; 61919-910; 70518-3186; 70010-084; 70010-085; 59762-5320; 70518-1756; 68084-996; 62559-580; 68788-7824; 70954-021; 70518-2065; 63629-8750; 50090-2845; 50090-0379; 51927-5040; 62559-581; 68788-8067; 70518-3271; 66993-433; 66993-431; 71205-585; 63629-8756; 71335-1724; 0093-4068; 66993-432; 70954-019; 0904-7020; 59762-5310; 51079-630; 60429-971; 70954-020; 68788-7849; 71335-1085; 59762-5350; 63809-2742; 60429-972; 71335-2042; 60687-572; 71335-1401; 50090-1948; 70518-2705; 71610-046; 0069-4260; 70518-3383; 0093-4069
Synonyms Prazosin | Furazosin | Prazosin Hydrochloride | Hydrochloride, Prazosin | Prazosin HCL | HCL, Prazosin | Minipress | Pratsiol
Chemical Information
Molecular Formula C19H22ClN5O4
CAS Registry Number 19237-84-4
SMILES COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Alopecia23.02.02.001--
Asthenia08.01.01.001--Not Available
Constipation07.02.02.001--
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dyspnoea22.02.01.004; 02.01.03.002--
Epistaxis22.04.03.001; 24.07.01.005--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Incontinence17.05.01.006; 07.01.06.011; 20.02.02.004--Not Available
Lichen planus23.03.08.001--Not Available
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005--
Pollakiuria20.02.02.007--
Priapism21.03.01.005--Not Available
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
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