Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Porfimer sodium
Drug ID BADD_D01803
Description The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in the United States.
Indications and Usage Indicated in the treatment of esophageal cancer.
Marketing Status Prescription
ATC Code L01XD01
DrugBank ID DB00707
KEGG ID D03327
MeSH ID D017323
PubChem ID 135577896
TTD Drug ID D02JDL
NDC Product Code 76128-155
Synonyms Dihematoporphyrin Ether | Ether, Dihematoporphyrin | Dihematoporphyrin Ester | Porfimer | DHP Ether | Porfimer Sodium | Photofrin | Photofrin II
Chemical Information
Molecular Formula C68H74N8O11
CAS Registry Number 87806-31-3
SMILES CC1=C(C2=CC3=NC(=CC4=NC(=CC5=C(C(=C(N5)C=C1N2)C(C)O)C)C(=C4C)C(C)OC(C)C6=C(C7=CC 8=C(C(=C(N8)C=C9C(=C(C(=N9)C=C1C(=C(C(=N1)C=C6N7)C)CCC(=O)O)CCC(=O)O)C)C)C(C)O)C )C(=C3CCC(=O)O)C)CCC(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Odynophagia07.05.03.001--Not Available
Oedema14.05.06.010; 08.01.07.0060.000533%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.001598%
Oesophageal haemorrhage24.07.02.021; 07.12.01.002--
Oesophageal pain07.01.05.012--
Oesophageal perforation07.04.05.0010.000799%
Oesophageal spasm07.02.04.004--Not Available
Oesophageal stenosis07.13.02.0010.001865%
Oesophageal ulcer07.04.05.0020.000208%
Oesophagitis07.08.05.001--
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Oxygen saturation decreased13.02.01.004--Not Available
Pain08.01.08.0040.000533%
Paraesthesia17.02.06.005--
Pericardial effusion02.06.01.002--
Peritonitis07.19.05.004; 11.01.07.007--
Pharyngitis11.01.13.003; 07.05.07.004; 22.07.03.004--
Phlebitis24.05.03.001; 12.02.01.002--
Photosensitivity reaction23.03.09.0030.000799%
Pleural effusion22.05.02.0020.001066%
Pneumonia22.07.01.003; 11.01.09.0030.001066%Not Available
Pneumonia aspiration22.01.01.005--Not Available
Pneumonitis22.01.01.006--
Pneumothorax22.05.02.0030.000799%
Productive cough22.02.03.005--
Protein total decreased13.09.01.004--Not Available
Pruritus23.03.12.001--
Pseudoporphyria23.03.01.006--Not Available
Pulmonary haemorrhage24.07.01.016; 22.02.04.003--
Pulmonary oedema22.01.03.003; 02.05.02.0030.000533%
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