Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Porfimer sodium
Drug ID BADD_D01803
Description The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in the United States.
Indications and Usage Indicated in the treatment of esophageal cancer.
Marketing Status Prescription
ATC Code L01XD01
DrugBank ID DB00707
KEGG ID D03327
MeSH ID D017323
PubChem ID 135577896
TTD Drug ID D02JDL
NDC Product Code 76128-155
Synonyms Dihematoporphyrin Ether | Ether, Dihematoporphyrin | Dihematoporphyrin Ester | Porfimer | DHP Ether | Porfimer Sodium | Photofrin | Photofrin II
Chemical Information
Molecular Formula C68H74N8O11
CAS Registry Number 87806-31-3
SMILES CC1=C(C2=CC3=NC(=CC4=NC(=CC5=C(C(=C(N5)C=C1N2)C(C)O)C)C(=C4C)C(C)OC(C)C6=C(C7=CC 8=C(C(=C(N8)C=C9C(=C(C(=N9)C=C1C(=C(C(=N1)C=C6N7)C)CCC(=O)O)CCC(=O)O)C)C)C(C)O)C )C(=C3CCC(=O)O)C)CCC(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain lower07.01.05.010--Not Available
Abdominal pain upper07.01.05.003--
Abdominal rigidity07.01.05.011--Not Available
Agitation19.06.02.001; 17.02.05.012--
Anaemia01.03.02.001--
Angina pectoris24.04.04.002; 02.02.02.002--
Anxiety19.06.02.002--
Asthenia08.01.01.001--Not Available
Atelectasis22.01.02.001--
Atrial fibrillation02.03.03.0020.001066%
Atrial flutter02.03.03.003--
Back pain15.03.04.005--
Basal cell carcinoma23.08.02.001; 16.03.02.001--Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Blood albumin decreased13.09.01.001--Not Available
Blood chloride increased13.11.01.005--Not Available
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Breath odour07.01.06.002--Not Available
Bronchial obstruction22.03.01.013--
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm22.03.01.004; 10.01.03.012--
Bronchostenosis22.03.01.020--
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Cardiac failure02.05.01.001--
Cataract06.06.01.001--
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