Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Porfimer
Drug ID BADD_D01802
Description The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in the United States.
Indications and Usage Indicated in the treatment of esophageal cancer.
Marketing Status Prescription
ATC Code L01XD01
DrugBank ID DB00707
KEGG ID D03327
MeSH ID D017323
PubChem ID 135577896
TTD Drug ID D02JDL
NDC Product Code 76128-155
Synonyms Dihematoporphyrin Ether | Ether, Dihematoporphyrin | Dihematoporphyrin Ester | Porfimer | DHP Ether | Porfimer Sodium | Photofrin | Photofrin II
Chemical Information
Molecular Formula C68H74N8O11
CAS Registry Number 87806-31-3
SMILES CC1=C(C2=CC3=NC(=CC4=NC(=CC5=C(C(=C(N5)C=C1N2)C(C)O)C)C(=C4C)C(C)OC(C)C6=C(C7=CC 8=C(C(=C(N8)C=C9C(=C(C(=N9)C=C1C(=C(C(=N1)C=C6N7)C)CCC(=O)O)CCC(=O)O)C)C)C(C)O)C )C(=C3CCC(=O)O)C)CCC(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haemorrhage24.07.01.002--Not Available
Post procedural complication12.02.05.018--Not Available
Angiopathy24.03.02.007--Not Available
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Infestation11.09.01.001; 23.09.05.001--Not Available
Inflammation08.01.05.007--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Porphyrin metabolism disorder14.14.01.006; 09.01.10.004; 03.08.01.006--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Carcinoma in situ16.16.01.006--Not Available
Blood disorder01.05.01.004--Not Available
Obstruction08.01.03.023--Not Available
Oesophageal neoplasm16.13.08.001; 07.21.04.004--Not Available
Increased bronchial secretion22.02.04.007--Not Available
Oesophageal oedema07.11.02.002--Not Available
Procedural pain12.02.05.007; 08.01.08.009--Not Available
Bronchial secretion retention22.03.02.008--Not Available
Regurgitation07.01.07.004--Not Available
Skin mass23.07.04.014--Not Available
Candida infection11.03.03.021--
Sinus node dysfunction02.03.03.017--
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