Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Porfimer
Drug ID BADD_D01802
Description The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in the United States.
Indications and Usage Indicated in the treatment of esophageal cancer.
Marketing Status Prescription
ATC Code L01XD01
DrugBank ID DB00707
KEGG ID D03327
MeSH ID D017323
PubChem ID 135577896
TTD Drug ID D02JDL
NDC Product Code 76128-155
Synonyms Dihematoporphyrin Ether | Ether, Dihematoporphyrin | Dihematoporphyrin Ester | Porfimer | DHP Ether | Porfimer Sodium | Photofrin | Photofrin II
Chemical Information
Molecular Formula C68H74N8O11
CAS Registry Number 87806-31-3
SMILES CC1=C(C2=CC3=NC(=CC4=NC(=CC5=C(C(=C(N5)C=C1N2)C(C)O)C)C(=C4C)C(C)OC(C)C6=C(C7=CC 8=C(C(=C(N8)C=C9C(=C(C(=N9)C=C1C(=C(C(=N1)C=C6N7)C)CCC(=O)O)CCC(=O)O)C)C)C(C)O)C )C(=C3CCC(=O)O)C)CCC(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pulmonary thrombosis24.01.06.002; 22.06.02.003--Not Available
Rash23.03.13.001--Not Available
Refraction disorder06.02.04.004--Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Sepsis11.01.11.003--
Sinusitis22.07.03.007; 11.01.13.005--
Skin discolouration23.03.03.005--Not Available
Skin disorder23.03.03.007--Not Available
Skin fragility23.03.03.009--Not Available
Skin wrinkling23.01.03.001--Not Available
Sputum increased22.02.03.007--Not Available
Stridor22.04.02.003--
Sunburn12.05.02.001; 23.03.09.007--Not Available
Supraventricular tachycardia02.03.03.012--
Swelling08.01.03.015--Not Available
Tachycardia02.03.02.007--Not Available
Tracheo-oesophageal fistula03.16.02.002; 22.04.07.003; 07.11.05.003--Not Available
Ulcer08.03.06.001--Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria23.04.02.001; 10.01.06.001--
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Tumour haemorrhage24.07.01.028; 16.32.03.008--
Fluid imbalance14.05.01.003--Not Available
Bronchial ulceration22.03.02.010--Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Lymphatic disorder01.09.01.003--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Nodule08.03.05.002--Not Available
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