Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Polyoxyethylene
Drug ID BADD_D01796
Description Polyethylene glycol (PEG) is a synthetic polymer produced via polymerization of ethylene oxide molecules to make joining units of ethylene glycol by an ether linkage.[A190975,A190978] PEGs are water-soluble polymers that can form hydrogen bonds in a ratio of 100 water molecules per one PEG molecule.[A190975] Molecular weights of PEGs vary by time of the polymerization process and the molecular weight represents the weighted average of the individual PEG molecules. PEGs differ in their physical and chemical properties depending on their molecular weight: PEGs are liquids when molecular weights are <1000 and the molecule turns to waxy solids with increasing molecular weights.[A190978] The most common preparations of PEGs include PEG 3350 and PEG 400. PEGs have various applications in many fields, ranging from medical to industrial areas. PEGs have a long history of gastroenterology: PEG 3350 is a common over-the-counter osmotic laxative used to relieve occasional constipation.[L11812] PEG 3350 is also used for cleansing of the colon in preparation for colonoscopy in adults.[L6421] The rationale of using PEG in gastroenterology is due to the physical properties of the compound: its potent water-binding capacity, negligible intestinal absorption with increasing molecular mass, lack of significant toxicity, and limited intestinal enzymatic degradation or bacterial metabolism all make PEG a useful therapeutic agent for the treatment of occasional constipation and bowel cleansing for preparation in colonoscopy.[A18713]
Indications and Usage Used to treat and prevent constipation.
Marketing Status Not Available
ATC Code A06AD15
DrugBank ID DB09287
KEGG ID D03370
MeSH ID D011092
PubChem ID Not Available
TTD Drug ID D0IV3M
NDC Product Code 59044-0009; 68001-505
Synonyms Polyethylene Glycols | Macrogol | Macrogols | Polyethylene Oxide | Oxide, Polyethylene | Oxides, Polyethylene | Polyethylene Oxides | Polyethyleneoxide | Polyethyleneoxides | Polyoxyethylenes | Polyoxyethylene | Polyglycol | Polyglycols | Polyethylene Glycol | Glycol, Polyethylene | Glycols, Polyethylene | Carbowax
Chemical Information
Molecular Formula Not Available
CAS Registry Number 25322-68-3
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema10.01.05.009; 23.04.01.001--Not Available
Cardiac arrest02.03.04.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Face oedema10.01.05.002; 08.01.07.003; 23.04.01.004--
Flatulence07.01.04.002--
Frequent bowel movements07.02.04.002--Not Available
Hypersensitivity10.01.03.003--
Mallory-Weiss syndrome24.07.02.038; 07.12.01.004--Not Available
Muscle spasms15.05.03.004--
Nasopharyngitis11.01.13.002; 22.07.03.002--Not Available
Nausea07.01.07.001--
Oesophageal perforation07.04.05.001--
Pulmonary oedema22.01.03.003; 02.05.02.003--
Rhinorrhoea22.02.05.010--
Tongue disorder07.14.01.002--Not Available
Tongue oedema07.14.02.007; 23.04.01.009; 10.01.05.008--Not Available
Upper gastrointestinal haemorrhage24.07.02.024; 07.12.02.006--
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
Anorectal discomfort07.03.03.003--Not Available
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