Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Podofilox
Drug ID BADD_D01790
Description A lignan found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
Indications and Usage For treatment of external genital warts (Condyloma acuminatum).
Marketing Status Prescription; Discontinued
ATC Code D06BB04
DrugBank ID DB01179
KEGG ID D05529
MeSH ID D011034
PubChem ID 10607
TTD Drug ID D0D4HN
NDC Product Code 63629-8832; 0023-6118; 66245-001; 0591-3204; 0574-0611
Synonyms Podophyllotoxin | Podofilox | Condylox | CPH86 | Epipodophyllotoxin | Podocon-25 | Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 beta))-Isomer | Podophyllotoxin, (5R-(5 alpha,5a alpha,8a beta,9 alpha))-Isomer | Podophyllotoxin, (5R-(5 alpha,5a beta,8a alpha,9 beta))-Isomer | Wartec | Warticon | Podofilm | Condyline | Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 alpha))-Isomer
Chemical Information
Molecular Formula C22H22O8
CAS Registry Number 518-28-5
SMILES COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Skin papilloma16.26.01.002; 11.05.07.001; 23.10.01.002--
Skin ulcer24.04.03.007; 23.07.03.003--
Swelling08.01.03.015--Not Available
Tenderness08.01.08.005--Not Available
Ulcer08.03.06.001--Not Available
Vomiting07.01.07.003--
Wound secretion08.01.03.035; 12.01.08.007--Not Available
Excoriation23.03.11.003; 12.01.06.007--Not Available
Skin burning sensation23.03.03.021; 17.02.06.009--Not Available
Haemorrhage24.07.01.002--Not Available
Inflammation08.01.05.007--Not Available
Chemical injury12.03.02.006--Not Available
Application site hypersensitivity12.07.01.014; 10.01.03.009; 08.02.01.013--Not Available
Application site haemorrhage24.07.01.048; 12.07.01.040; 08.02.01.040--Not Available
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