Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pirfenidone
Drug ID BADD_D01783
Description Pirfenidone is an orally active small molecule drug that may inhibit collagen synthesis, down regulate production of multiple cytokines and block fibroblast proliferation and stimulation in response to cytokines. Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver. It is being investigated by InterMune.
Indications and Usage For the treatment of idiopathic pulmonary fibrosis (IPF).
Marketing Status Prescription; Discontinued
ATC Code L04AX05
DrugBank ID DB04951
KEGG ID D01583
MeSH ID C093844
PubChem ID 40632
TTD Drug ID D02WCI
NDC Product Code 65372-1197; 46708-907; 73309-052; 46016-5310; 62207-004; 62512-0070; 69037-0013; 53104-7712; 11014-0214; 59285-013; 76072-1006; 69766-030; 50242-122; 57297-140; 46016-5312; 46438-0648; 60219-1642; 50242-121; 50242-123; 59651-199; 60219-1640; 60219-1641; 60862-005; 42571-329; 63759-7005
Synonyms pirfenidone | 5-methyl-1-phenyl-2-(1H)-pyridone | Esbriet | deupirfenidone | 1-phenyl-5-(trideuteriomethyl)-1,2-dihydropyridin-2-one | Deskar
Chemical Information
Molecular Formula C12H11NO
CAS Registry Number 53179-13-8
SMILES CC1=CN(C(=O)C=C1)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Influenza22.07.02.001; 11.05.03.0010.011001%Not Available
Influenza like illness08.01.03.010--
Inguinal hernia07.16.02.0010.003474%Not Available
Initial insomnia19.02.01.005; 17.15.03.0050.002316%Not Available
Insomnia17.15.03.002; 19.02.01.0020.033582%
International normalised ratio decreased13.01.02.0070.001737%Not Available
Interstitial lung disease22.01.02.003; 10.02.01.0330.001812%Not Available
Intestinal obstruction07.13.01.002--Not Available
Irritability19.04.02.013; 08.01.03.011--
Irritable bowel syndrome19.24.01.003; 07.02.04.0030.001158%Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Joint swelling15.01.02.004--Not Available
Kidney infection20.01.09.004; 11.01.14.0060.001158%
Laboratory test abnormal13.18.01.001--Not Available
Laceration23.03.11.004; 12.01.06.006--Not Available
Lacrimation increased06.08.02.0040.002316%
Lethargy17.02.04.003; 19.04.04.004; 08.01.01.0080.009264%
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Lip oedema23.04.01.006; 10.01.05.004; 07.05.04.0040.001737%Not Available
Listless19.04.04.003; 08.01.01.0120.001158%Not Available
Liver disorder09.01.08.001--Not Available
Liver function test abnormal13.03.01.0130.007527%Not Available
Loss of consciousness17.02.04.004--Not Available
Lower respiratory tract infection22.07.01.002; 11.01.09.0020.009264%Not Available
Lung disorder22.02.07.0010.006948%Not Available
Lung infiltration22.01.02.0040.000302%Not Available
Lymphopenia01.02.02.002--Not Available
Malaise08.01.01.0030.067163%
Melaena24.07.02.013; 07.12.02.004--Not Available
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