Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pirfenidone
Drug ID BADD_D01783
Description Pirfenidone is an orally active small molecule drug that may inhibit collagen synthesis, down regulate production of multiple cytokines and block fibroblast proliferation and stimulation in response to cytokines. Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver. It is being investigated by InterMune.
Indications and Usage For the treatment of idiopathic pulmonary fibrosis (IPF).
Marketing Status Prescription; Discontinued
ATC Code L04AX05
DrugBank ID DB04951
KEGG ID D01583
MeSH ID C093844
PubChem ID 40632
TTD Drug ID D02WCI
NDC Product Code 65372-1197; 46708-907; 73309-052; 46016-5310; 62207-004; 62512-0070; 69037-0013; 53104-7712; 11014-0214; 59285-013; 76072-1006; 69766-030; 50242-122; 57297-140; 46016-5312; 46438-0648; 60219-1642; 50242-121; 50242-123; 59651-199; 60219-1640; 60219-1641; 60862-005; 42571-329; 63759-7005
Synonyms pirfenidone | 5-methyl-1-phenyl-2-(1H)-pyridone | Esbriet | deupirfenidone | 1-phenyl-5-(trideuteriomethyl)-1,2-dihydropyridin-2-one | Deskar
Chemical Information
Molecular Formula C12H11NO
CAS Registry Number 53179-13-8
SMILES CC1=CN(C(=O)C=C1)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dry mouth07.06.01.0020.001812%
Dry skin23.03.03.0010.006369%
Dysgeusia17.02.07.003; 07.14.03.0010.020844%
Dyspepsia07.01.02.0010.039950%
Dysphagia07.01.06.0030.015054%
Dysphonia19.19.03.002; 17.02.08.004; 22.02.05.005--
Dyspnoea22.02.01.004; 02.01.03.0020.114061%
Dyspnoea exertional22.02.01.005; 02.01.03.0030.003474%Not Available
Dysuria20.02.02.002--
Eating disorder19.09.01.008; 14.03.01.0080.002417%Not Available
Eczema23.03.04.0060.003474%
Electrocardiogram abnormal13.14.05.0010.001158%Not Available
Electrolyte imbalance14.05.01.0020.001158%Not Available
Emphysema22.01.02.0020.000453%Not Available
Eosinophilia01.02.04.0010.002895%
Epistaxis24.07.01.005; 22.04.03.001--
Eructation07.01.02.0030.004053%
Erythema23.03.06.0010.020265%Not Available
Erythema multiforme23.03.01.003; 10.01.03.0150.001737%
Extrasystoles02.03.02.0030.001158%Not Available
Eye irritation06.04.05.003--Not Available
Eye swelling06.08.03.003--Not Available
Face oedema08.01.07.003; 23.04.01.004; 10.01.05.002--
Fasciitis15.03.03.0010.001158%Not Available
Fatigue08.01.01.0020.147064%
Feeling abnormal08.01.09.014--Not Available
Feeling cold08.01.09.0080.001359%Not Available
Feeling hot08.01.09.009--Not Available
Feeling jittery08.01.09.016--Not Available
Fibrosis08.03.01.0010.000302%Not Available
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