Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pirfenidone
Drug ID BADD_D01783
Description Pirfenidone is an orally active small molecule drug that may inhibit collagen synthesis, down regulate production of multiple cytokines and block fibroblast proliferation and stimulation in response to cytokines. Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver. It is being investigated by InterMune.
Indications and Usage For the treatment of idiopathic pulmonary fibrosis (IPF).
Marketing Status Prescription; Discontinued
ATC Code L04AX05
DrugBank ID DB04951
KEGG ID D01583
MeSH ID C093844
PubChem ID 40632
TTD Drug ID D02WCI
NDC Product Code 65372-1197; 46708-907; 73309-052; 46016-5310; 62207-004; 62512-0070; 69037-0013; 53104-7712; 11014-0214; 59285-013; 76072-1006; 69766-030; 50242-122; 57297-140; 46016-5312; 46438-0648; 60219-1642; 50242-121; 50242-123; 59651-199; 60219-1640; 60219-1641; 60862-005; 42571-329; 63759-7005
Synonyms pirfenidone | 5-methyl-1-phenyl-2-(1H)-pyridone | Esbriet | deupirfenidone | 1-phenyl-5-(trideuteriomethyl)-1,2-dihydropyridin-2-one | Deskar
Chemical Information
Molecular Formula C12H11NO
CAS Registry Number 53179-13-8
SMILES CC1=CN(C(=O)C=C1)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bronchiectasis22.03.02.0050.000302%Not Available
Bronchitis22.07.01.001; 11.01.09.0010.009264%
Burning sensation08.01.09.029; 17.02.06.001--Not Available
Cachexia16.32.03.011; 14.03.02.001; 08.01.01.0090.000453%Not Available
Cardiac arrest02.03.04.0010.004229%
Cardiac failure02.05.01.0010.003927%
Cardiac failure acute02.05.01.0050.000302%Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Cardiogenic shock24.06.02.006; 02.05.01.003--Not Available
Cataract06.06.01.0010.004632%
Cellulitis23.09.01.001; 11.02.01.0010.005211%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebral thrombosis17.08.01.006; 24.01.04.0030.001158%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.0030.024897%Not Available
Chills15.05.03.016; 08.01.09.001--
Cholecystitis09.03.01.0010.001737%
Cholelithiasis09.03.01.0020.004053%Not Available
Cholestasis09.01.01.001--Not Available
Chromaturia20.02.01.0020.005790%
Chronic obstructive pulmonary disease22.03.01.0070.001510%Not Available
Cold sweat23.02.03.002; 08.01.03.0240.001737%Not Available
Colitis07.08.01.0010.004053%
Colitis ulcerative10.02.01.004; 07.08.01.0050.001737%Not Available
Colon cancer16.13.01.001; 07.21.01.0010.000604%Not Available
Coma17.02.09.001--Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
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