Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pioglitazone hydrochloride
Drug ID BADD_D01778
Description Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in vivo_ with little consequence.[L11416] The thiazolidinedione class of medications, which also includes [rosiglitazone] and [troglitazone], exerts its pharmacological effect primarily by promoting insulin sensitivity and the improved uptake of blood glucose[L11416] via agonism at the peroxisome proliferator-activated receptor-gamma (PPARγ).[A19757] PPARs are ligand-activated transcription factors that are involved in the expression of more than 100 genes and affect numerous metabolic processes, most notably lipid and glucose homeostasis.[A19759] Thiazolidinediones, including pioglitazone, have fallen out of favor in recent years due to the presence of multiple adverse effects and warnings regarding their use (e.g. congestive heart failure, bladder cancer) and the availability of safer and more effective alternatives for patients with type 2 diabetes mellitus.[L11461]
Indications and Usage Pioglitazone is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus [FDA Label].
Marketing Status Prescription
ATC Code A10BG03
DrugBank ID DB01132
KEGG ID D00945
MeSH ID D000077205
PubChem ID 60560
NDC Product Code 65862-514; 68071-1620; 72606-570; 62147-0020; 55111-052; 68071-4035; 63629-3292; 65862-513; 63629-3330; 68788-6888; 52343-055; 65862-508; 68788-6419; 72606-503; 62147-0005; 53104-7566; 43353-326; 62147-0071; 65015-708; 65862-512; 52343-054; 50090-5582; 66332-0013; 71610-522; 72189-292; 52343-053; 68554-0030; 65727-006; 62147-0070; 66332-0012; 68071-1729; 72606-572; 68071-2170; 72606-502; 59361-003; 72606-501; 66332-0011; 71335-2027; 50379-0008; 65096-0104; 72606-571; 71610-497; 63629-3299; 11532-5001
Synonyms Pioglitazone | 5-(4-(2-(5-Ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione | U 72107A | U72,107A | U-72107A | U72107A | AD 4833 | AD-4833 | AD4833 | Pioglitazone Hydrochloride | Actos
Chemical Information
Molecular Formula C19H21ClN2O3S
CAS Registry Number 112529-15-4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal weight gain14.03.02.010--Not Available
Alanine aminotransferase increased13.03.01.003--
Back pain15.03.04.005--
Bladder neoplasm20.03.04.002; Available
Blood creatine phosphokinase increased13.04.01.001--
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardiovascular disorder24.03.02.009; Available
Cerebrovascular accident24.03.05.001;
Chest pain22.02.08.003;; Available
Coronary artery bypass25.03.03.003--Not Available
Diabetic retinal oedema05.07.01.001;; Available
Haematocrit decreased13.01.05.001--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Hepatic failure09.01.03.002--
Leg amputation25.14.01.001--Not Available
Myocardial infarction24.04.04.009;
Oedema14.05.06.010; Available
Pain in extremity15.03.04.010--
The 1th Page    1 2    Next   Last    Total 2 Pages