Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pilocarpine hydrochloride
Drug ID BADD_D01771
Description A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
Indications and Usage For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome.
Marketing Status Discontinued; Prescription
ATC Code N07AX01; S01EB01
DrugBank ID DB01085
KEGG ID D02200
MeSH ID D010862
PubChem ID 5909
TTD Drug ID D06HLY
NDC Product Code 63629-2099; 17478-224; 0115-5911; 0074-7098; 0998-0204; 69205-001; 69238-1745; 69238-1746; 59212-775; 50384-0400; 59651-225; 38779-0182; 61314-204; 0527-1313; 17478-223; 51927-1528; 0228-2837; 0115-5922; 0998-0206; 16714-122; 61314-203; 50268-652; 0998-0203; 16714-121; 0228-2801; 63279-100; 17478-226; 0527-1407; 59651-224; 63629-8351; 12538-1921; 61314-206; 69238-1747; 68084-928; 59212-705
Synonyms Pilocarpine | Isoptocarpine | Salagen | Pilocarpine Hydrochloride | Hydrochloride, Pilocarpine | Pilocarpine, Monohydrochloride, (3S-cis)-Isomer | Pilocarpine Nitrate | Nitrate, Pilocarpine | Pilocarpine Mononitrate, (3S-cis)-Isomer | Isopilocarpine | Ocusert
Chemical Information
Molecular Formula C11H17ClN2O2
CAS Registry Number 54-71-7
SMILES CCC1C(COC1=O)CC2=CN=CN2C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Seizures (incl subtypes)Delta-type opioid receptorP41143T58992Not Available
Seizures (incl subtypes)Mu-type opioid receptorP35372T47768Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Muscle twitching15.05.03.005--Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Neck pain15.03.04.009--
Nervousness19.06.02.003--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oesophagitis07.08.05.001--
Ovarian disorder21.11.02.004--Not Available
Pain08.01.08.004--
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005--
Parotid gland enlargement07.06.03.001--Not Available
Pathological fracture16.32.03.007; 15.08.02.008; 12.04.02.006--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photosensitivity reaction23.03.09.003--
Platelet disorder01.08.03.001--Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pollakiuria20.02.02.007--
Presyncope24.06.02.010; 17.02.05.009; 02.01.02.007--
Pruritus23.03.12.001--
Psychomotor hyperactivity19.11.02.003; 17.01.02.011--Not Available
Pulmonary oedema22.01.03.003; 02.05.02.003--
Pyrexia08.05.02.003--
Pyuria20.02.01.012; 11.01.08.043--Not Available
Rash23.03.13.001--Not Available
Rash pustular23.03.10.003; 11.01.12.002--
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