Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pilocarpine hydrochloride
Drug ID BADD_D01771
Description A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
Indications and Usage For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome.
Marketing Status Discontinued; Prescription
ATC Code N07AX01; S01EB01
DrugBank ID DB01085
KEGG ID D02200
MeSH ID D010862
PubChem ID 5909
TTD Drug ID D06HLY
NDC Product Code 63629-2099; 17478-224; 0115-5911; 0074-7098; 0998-0204; 69205-001; 69238-1745; 69238-1746; 59212-775; 50384-0400; 59651-225; 38779-0182; 61314-204; 0527-1313; 17478-223; 51927-1528; 0228-2837; 0115-5922; 0998-0206; 16714-122; 61314-203; 50268-652; 0998-0203; 16714-121; 0228-2801; 63279-100; 17478-226; 0527-1407; 59651-224; 63629-8351; 12538-1921; 61314-206; 69238-1747; 68084-928; 59212-705
Synonyms Pilocarpine | Isoptocarpine | Salagen | Pilocarpine Hydrochloride | Hydrochloride, Pilocarpine | Pilocarpine, Monohydrochloride, (3S-cis)-Isomer | Pilocarpine Nitrate | Nitrate, Pilocarpine | Pilocarpine Mononitrate, (3S-cis)-Isomer | Isopilocarpine | Ocusert
Chemical Information
Molecular Formula C11H17ClN2O2
CAS Registry Number 54-71-7
SMILES CCC1C(COC1=O)CC2=CN=CN2C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Seizures (incl subtypes)Mu-type opioid receptorP35372T47768Not Available
Seizures (incl subtypes)Delta-type opioid receptorP41143T58992Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Ageusia17.02.07.001; 07.14.03.003--Not Available
Agitation17.02.05.012; 19.06.02.001--
Alopecia23.02.02.001--
Amblyopia06.02.01.001--Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Anxiety19.06.02.002--
Aphasia19.21.01.001; 17.02.03.001--
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Asthenia08.01.01.001--Not Available
Atrioventricular block02.03.01.002--Not Available
Back pain15.03.04.005--
Blepharospasm17.17.02.001; 06.05.01.001--Not Available
Body temperature decreased13.15.01.010--Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.004--Not Available
Bradycardia02.03.02.002--Not Available
Breast pain21.05.05.003--
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm10.01.03.012; 22.03.01.004--
Cataract06.06.01.001--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills08.01.09.001; 15.05.03.016--
Cholelithiasis09.03.01.002--Not Available
Ciliary muscle spasm17.17.02.002; 06.05.03.001--Not Available
Colitis07.08.01.001--
Confusional state19.13.01.001; 17.02.03.005--
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