Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Phenylpropanolamine
Drug ID BADD_D01764
Description Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes.
Indications and Usage For the treatment of nasal congestion, control of urinary incontinence, priapism and obesity.
Marketing Status Not Available
ATC Code R01BA01
DrugBank ID DB00397
KEGG ID D08368
MeSH ID D010665
PubChem ID 4786
TTD Drug ID D09JXM
NDC Product Code 63083-1534
Synonyms Phenylpropanolamine | Norephedrine | Propagest | Phenylpropanolamine Hydrochloride | Hydrochloride, Phenylpropanolamine | Prolamine | Triaminic DM | Dexatrim
Chemical Information
Molecular Formula C9H13NO
CAS Registry Number 14838-15-4
SMILES CC(C(C1=CC=CC=C1)O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation17.02.05.012; 19.06.02.001--
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Blood pressure increased13.14.03.005--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Coordination abnormal17.02.02.004--Not Available
Dermatitis23.03.04.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyskinesia17.01.02.006--
Dysphoria19.04.02.004--Not Available
Dyspnoea22.02.01.004; 02.01.03.002--
Euphoric mood19.04.02.006--
Feeling abnormal08.01.09.014--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Hallucination19.10.02.002--
Hepatocellular injury09.01.07.008--Not Available
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Insomnia19.02.01.002; 17.15.03.002--
Irritability19.04.02.013; 08.01.03.011--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Rash23.03.13.001--Not Available
Renal tubular necrosis20.01.07.003--Not Available
Respiratory depression17.02.05.047; 22.02.01.010--Not Available
Serotonin syndrome17.05.02.004; 15.05.04.016; 12.03.01.041--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Tachycardia02.03.02.007--Not Available
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