Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Phenylephrine
Drug ID BADD_D01762
Description Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil,[L9413] and induce local vasoconstriction.[A187370] The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.[A187376] Phenylephrine was granted FDA approval in 1939.[L9413]
Indications and Usage Phenylephrine is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs.
Marketing Status Prescription
ATC Code C01CA06; R01AA04; R01AB01; R01BA03; S01FB01; S01GA05
DrugBank ID DB00388
KEGG ID D08365
MeSH ID D010656
PubChem ID 6041
TTD Drug ID D0O6IU
NDC Product Code 42961-205; 0498-3331; 57218-710; 0498-3330
Synonyms Phenylephrine | (R)-3-Hydroxy-alpha-((methylamino)methyl)benzenemethanol | Metasympatol | Mezaton | Phenylephrine Hydrochloride | Phenylephrine Tannate | Tannate, Phenylephrine | Metaoxedrin | Neo-Synephrine | Neo Synephrine | Neosynephrine
Chemical Information
Molecular Formula C9H13NO2
CAS Registry Number 59-42-7
SMILES CNCC(C1=CC(=CC=C1)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rales22.02.04.004--Not Available
Retinopathy06.10.02.001; 24.03.07.0030.009111%
Shock24.06.02.002--Not Available
Sinus bradycardia02.03.03.0090.006074%
Skin disorder23.03.03.007--Not Available
Skin exfoliation23.03.07.003--Not Available
Skin necrosis23.03.03.011--Not Available
Somnolence19.02.05.003; 17.02.04.0060.015184%
Subarachnoid haemorrhage17.08.01.010; 12.01.10.011; 24.07.04.0040.003169%Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.0080.006074%
Tachycardia02.03.02.0070.018221%Not Available
Tension19.06.02.005--Not Available
Torsade de pointes02.03.04.0050.018221%Not Available
Tremor17.01.06.0020.006074%
Unresponsive to stimuli17.02.05.0310.006074%Not Available
Vasospasm24.04.02.0020.006074%Not Available
Ventricular arrhythmia02.03.04.006--
Ventricular extrasystoles02.03.04.007--Not Available
Ventricular fibrillation02.03.04.0080.006074%
Ventricular tachycardia02.03.04.0100.006074%
Vision blurred17.17.01.010; 06.02.06.0070.006074%
Vitreous floaters06.09.01.005--
Vomiting07.01.07.0030.036443%
Underweight14.03.02.017--Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Haemodynamic instability24.03.02.0060.009111%Not Available
Pulseless electrical activity02.03.04.0200.006074%Not Available
Angiopathy24.03.02.007--Not Available
Cardiac disorder02.01.01.003--Not Available
Ischaemia24.04.02.004--Not Available
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