Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Phenobarbital
Drug ID BADD_D01752
Description A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Indications and Usage For the treatment of all types of seizures except absence seizures.
Marketing Status Not Available
ATC Code N03AA02
DrugBank ID DB01174
KEGG ID D00506
MeSH ID D010634
PubChem ID 4763
TTD Drug ID D0Y7RW
NDC Product Code 58118-0626; 16571-673; 69336-115; 75826-136; 71205-889; 0143-1495; 17856-0502; 66064-2001; 63629-2404; 16571-668; 63629-2289; 70752-167; 0603-5166; 70518-0822; 69367-212; 76003-0894; 16571-669; 51927-1015; 67296-1427; 0603-5165; 70518-2612; 51293-626; 16571-674; 69367-214; 63629-2043; 70752-162; 63629-2049; 63739-294; 58118-1110; 16571-675; 69367-213; 64380-166; 71205-892; 70752-168; 63739-192; 13517-111; 63629-2045; 70752-161; 65319-1450; 0143-1458; 0603-5167; 63629-2044; 13517-110; 51293-627; 63629-2402; 51293-693; 75826-143; 38779-0852; 51293-694; 63187-895; 63629-2047; 51293-692; 43063-953; 70752-165; 70518-0722; 70752-164; 70752-166; 17856-0174; 63629-2046; 51293-625; 69367-211; 70518-2418; 63629-2401; 71205-891; 59348-0011; 63629-2041; 13517-758; 70166-536; 71205-890; 13517-756; 69336-116; 60687-448; 69336-117; 13517-113; 13517-112; 0121-0531; 63629-2400; 0143-1455; 63629-2403; 70518-2407; 58624-0520; 70166-537; 16571-667; 0603-5168; 75826-142; 0904-6575; 63629-2291; 61919-109; 75826-141; 70752-163; 63629-2399; 63629-2042; 70518-2405; 13517-755; 16571-671; 63629-2290; 0143-1500; 75826-139; 75826-138; 69367-172; 51552-0745; 16571-672; 13517-757; 51293-691; 16571-670; 63629-2048; 63629-1033; 13517-107; 69336-118; 51293-628; 49452-5190; 0395-8090; 71205-893; 54932-207; 75826-137; 0603-1508; 54932-501; 63629-1032; 75826-140; 70752-157
Synonyms Phenobarbital | Phenylbarbital | Phenylethylbarbituric Acid | Acid, Phenylethylbarbituric | Phenemal | Phenobarbitone | Hysteps | Phenobarbital Sodium | Sodium, Phenobarbital | Phenobarbital, Monosodium Salt | Monosodium Salt Phenobarbital | Luminal | Gardenal
Chemical Information
Molecular Formula C12H12N2O3
CAS Registry Number 50-06-6
SMILES CCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Toxicity to various agentsCytochrome P450 3A4P08684T37848Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dermatitis bullous23.03.01.002--
Dermatitis exfoliative23.03.07.001; 10.01.01.0040.001490%
Developmental delay08.01.03.037--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.002235%
Drug hypersensitivity10.01.01.001--Not Available
Dry mouth07.06.01.002--
Dyspnoea22.02.01.004; 02.01.03.0020.002235%
Ear infection04.03.01.006; 11.01.05.0010.001490%Not Available
Electroencephalogram abnormal13.07.03.0010.001490%Not Available
Emotional disorder19.04.02.005--Not Available
Eosinophilia01.02.04.0010.002235%
Epilepsy17.12.03.0020.002235%Not Available
Erythema23.03.06.001--Not Available
Erythema multiforme10.01.03.015; 23.03.01.003--
Extravasation08.01.03.008--Not Available
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.004--Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.0030.001490%
Failure to thrive14.03.02.008; 19.07.05.001; 18.04.01.0030.000389%Not Available
Fanconi syndrome20.05.03.009; 14.01.01.011; 03.06.01.0010.001490%Not Available
Feeling abnormal08.01.09.014--Not Available
Folate deficiency14.12.02.006--Not Available
Hallucination19.10.02.002--
Hangover08.01.09.018--Not Available
Headache17.14.01.001--
Hepatitis09.01.07.0040.001490%Not Available
Hepatocellular injury09.01.07.008--Not Available
Human herpesvirus 6 infection11.05.02.0200.002235%Not Available
Hyperkinesia17.01.02.008--Not Available
Hypersensitivity10.01.03.003--
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