Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Perphenazine
Drug ID BADD_D01743
Description An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.
Indications and Usage For use in the management of the manifestations of psychotic disorders and for the control of severe nausea and vomiting in adults.
Marketing Status Prescription; Discontinued
ATC Code N05AB03
DrugBank ID DB00850
KEGG ID D00503
MeSH ID D010546
PubChem ID 4748
TTD Drug ID D02HED
NDC Product Code 70518-3033; 70518-0940; 52536-164; 70518-1125; 0591-4103; 0591-4102; 0781-8046; 0591-4104; 63629-2251; 70518-0710; 0781-8047; 0603-5062; 68084-602; 63629-2250; 52536-168; 0781-8048; 68382-594; 70518-2639; 0603-5060; 70518-2985; 0904-6600; 64980-293; 65372-1191; 70771-1043; 68084-607; 52536-170; 70518-3018; 0603-5061; 70518-2890; 0904-6601; 63629-2248; 0591-4101; 64980-292; 70518-0458; 0603-5063; 70518-0731; 63629-2253; 70771-1044; 68382-592; 70518-3108; 70518-3106; 70518-1109; 70771-1041; 63629-2252; 70518-3257; 64980-290; 70518-1739; 68382-591; 63629-2249; 46204-0003; 70518-3121; 63629-7252; 52536-162; 68382-593; 53808-1124; 0781-8049; 42973-165; 64980-291; 70518-1133; 70771-1042; 0904-6599
Synonyms Perphenazine | Perfenazine | Chlorpiprazine | Trilafon
Chemical Information
Molecular Formula C21H26ClN3OS
CAS Registry Number 58-39-9
SMILES C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Photophobia17.17.02.006; 06.01.01.004--
Photosensitivity reaction23.03.09.003--
Polyuria20.02.03.002--Not Available
Pregnancy test false positive13.10.05.003--Not Available
Protrusion tongue17.02.05.037; 07.14.02.002--Not Available
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Retinal disorder06.08.03.005--Not Available
Retinal pigmentation06.09.03.008--Not Available
Salivary hypersecretion07.06.01.009--Not Available
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Sudden death08.04.01.003; 02.03.04.013--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Systemic lupus erythematosus23.03.02.006; 15.06.02.003; 10.04.03.004--Not Available
Tachycardia02.03.02.007--Not Available
Tardive dyskinesia17.01.02.012--Not Available
Throat tightness22.02.05.015; 19.01.02.005--Not Available
Thrombocytopenic purpura01.08.01.003; 23.06.01.007--Not Available
Tongue discolouration07.14.02.006--Not Available
Torticollis17.01.03.003; 15.05.04.003--Not Available
Trismus17.01.03.004; 15.05.04.004--
Urinary retention20.02.02.011--
Urticaria10.01.06.001; 23.04.02.001--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Brain oedema12.01.10.010; 17.07.02.003--
Inappropriate antidiuretic hormone secretion14.05.07.001; 05.03.03.001--Not Available
Faecaloma07.01.03.004--Not Available
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