Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Periciazine
Drug ID BADD_D01738
Description Periciazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects and an action on the extrapyramidal system. It is used as an adjunctive medication in some psychotic patients, for the control of residual prevailing hostility, impulsiveness and aggressiveness. Pericyazine, like other phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a central adrenergic blockade.
Indications and Usage For use as adjunctive medication in some psychotic patients. Propericiazine (Pericyazine)is used for the control of residual prevailing hostility, impulsiveness and aggressiveness.
Marketing Status Not Available
ATC Code N05AC01
DrugBank ID DB01608
KEGG ID D01485
MeSH ID C084584
PubChem ID 4747
TTD Drug ID D00AWT
NDC Product Code Not Available
Synonyms periciazine | propericiazine | pericyazine | Neuleptil | Neuleptyl | Aolept
Chemical Information
Molecular Formula C21H23N3OS
CAS Registry Number 2622-26-6
SMILES C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Sudden death08.04.01.003; 02.03.04.013--
Tachycardia02.03.02.007--Not Available
Tardive dyskinesia17.01.02.012--Not Available
Tremor17.01.06.002--
Ventricular tachycardia02.03.04.010--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Weight increased13.15.01.006--
Deep vein thrombosis24.01.02.003--Not Available
Electrocardiogram U-wave abnormality13.14.05.028--Not Available
Cardiac disorder02.01.01.003--Not Available
Erectile dysfunction21.03.01.007; 19.08.04.001--
Cardiac fibrillation02.03.02.021--Not Available
Pulmonary function test decreased13.19.01.001--Not Available
Pigmentation disorder23.05.03.001--Not Available
Liver injury12.01.02.003; 09.01.07.022--Not Available
Traumatic liver injury12.01.02.008; 09.01.08.010--Not Available
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