Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pentamidine
Drug ID BADD_D01717
Description Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Indications and Usage For the treatment of pneumonia due to Pneumocystis carinii.
Marketing Status approved; investigational
ATC Code P01CX01
DrugBank ID DB00738
KEGG ID D08333
MeSH ID D010419
PubChem ID 4735
TTD Drug ID D05EAM
NDC Product Code Not Available
UNII 673LC5J4LQ
Synonyms Pentamidine | Pentamidin | Lomidine | NebuPent | Pentamidine Isethionate | Pentam | Pentamidine Mesylate | Diamidine | Pentacarinat
Chemical Information
Molecular Formula C19H24N4O2
CAS Registry Number 100-33-4
SMILES C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Cough22.02.03.0010.000694%
Cyanosis23.06.04.005; 02.11.04.004; 24.03.01.007; 22.02.02.007--
Dermatitis23.03.04.002--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.11.04.006--
Drug hypersensitivity10.01.01.0010.000482%Not Available
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Dysgeusia17.02.07.003; 07.14.03.0010.000312%
Dyspepsia07.01.02.001--
Dysphonia17.02.08.004; 22.12.03.006; 19.19.03.0020.000142%
Dyspnoea02.11.05.003; 22.02.01.0040.001998%
Ear infection11.01.05.001; 04.03.01.006--Not Available
Electrocardiogram QT prolonged13.14.05.004--
Electrocardiogram ST segment13.14.05.035--Not Available
Encephalitis viral17.06.06.002; 11.05.04.010--Not Available
Eosinophilia01.02.04.001--
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Extravasation08.01.03.008--Not Available
Eye pain06.08.03.002--
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Flank pain20.02.03.006; 15.03.04.003; 08.01.08.007--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.001445%
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ADReCS-Target
Drug Name ADR Term Target
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