Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pemetrexed
Drug ID BADD_D01701
Description Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the brand name Alimta. It is indicated for use in combination with cisplatin for the treatment of patients with malignant pleural mesothelioma whose disease is either unresectable or who are otherwise not candidates for curative surgery. Its use in non-small cell lung cancer has also been investigated.
Indications and Usage Used in combination with cisplatin for the treatment of malignant pleural mesothelioma in adults whose disease is unresectable or who otherwise are not candidates for potentially curative surgery. Also used as a monotherapy for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy
Marketing Status Prescription
ATC Code L01BA04
DrugBank ID DB00642
KEGG ID D07472
MeSH ID D000068437
PubChem ID 135410875
TTD Drug ID D0Y4GO
NDC Product Code 65129-1366; 42367-531; 47848-026
Synonyms Pemetrexed | MTA | N-(4-(2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid | Pemetrexed Disodium | Disodium, Pemetrexed | LY 231514 | 231514, LY | LY-231,514 | LY231514 | LY 231,514 | 231,514, LY | LY-231514 | Alimta
Chemical Information
Molecular Formula C20H21N5O6
CAS Registry Number 137281-23-3
SMILES C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Skin discolouration23.03.03.0050.000533%Not Available
Skin disorder23.03.03.0070.000533%Not Available
Skin exfoliation23.03.07.003--Not Available
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Stomatitis07.05.06.0050.000139%
Syncope24.06.02.012; 17.02.04.008; 02.01.02.0080.000799%
Tachycardia02.03.02.0070.000533%Not Available
Tachypnoea22.02.01.0140.000533%Not Available
Thrombocytopenia01.08.01.0020.005328%Not Available
Thrombosis24.01.01.006--Not Available
Toxic epidermal necrolysis12.03.01.015; 11.07.01.006; 10.01.01.006; 23.03.01.008--
Transient ischaemic attack24.04.06.005; 17.08.04.001--
Unresponsive to stimuli17.02.05.0310.000533%Not Available
Urethral disorder20.07.01.002--Not Available
Urinary tract disorder20.08.01.001--Not Available
Urticaria23.04.02.001; 10.01.06.0010.000799%
Ventricular fibrillation02.03.04.0080.000533%
Ventricular tachycardia02.03.04.010--
Vomiting07.01.07.0030.002931%
Weight decreased13.15.01.0050.001066%
White blood cell count decreased13.01.06.012--
Tubulointerstitial nephritis20.05.02.0020.000533%Not Available
Radiation oesophagitis12.05.02.008; 07.08.05.005--Not Available
Performance status decreased08.01.03.0420.000799%Not Available
Peripheral swelling08.01.03.053; 02.05.04.015--Not Available
Anal sphincter atony17.05.02.009; 07.03.01.0030.000533%Not Available
Deep vein thrombosis24.01.02.003--Not Available
Malignant neoplasm progression16.16.01.0050.001112%Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.0150.000799%Not Available
Lymphatic disorder01.09.01.003--Not Available
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