Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pemetrexed
Drug ID BADD_D01701
Description Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the brand name Alimta. It is indicated for use in combination with cisplatin for the treatment of patients with malignant pleural mesothelioma whose disease is either unresectable or who are otherwise not candidates for curative surgery. Its use in non-small cell lung cancer has also been investigated.
Indications and Usage Used in combination with cisplatin for the treatment of malignant pleural mesothelioma in adults whose disease is unresectable or who otherwise are not candidates for potentially curative surgery. Also used as a monotherapy for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy
Marketing Status Prescription
ATC Code L01BA04
DrugBank ID DB00642
KEGG ID D07472
MeSH ID D000068437
PubChem ID 135410875
TTD Drug ID D0Y4GO
NDC Product Code 65129-1366; 42367-531; 47848-026
Synonyms Pemetrexed | MTA | N-(4-(2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid | Pemetrexed Disodium | Disodium, Pemetrexed | LY 231514 | 231514, LY | LY-231,514 | LY231514 | LY 231,514 | 231,514, LY | LY-231514 | Alimta
Chemical Information
Molecular Formula C20H21N5O6
CAS Registry Number 137281-23-3
SMILES C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Lactic acidosis14.01.01.0020.001066%Not Available
Leukopenia01.02.02.0010.001332%Not Available
Lip oedema10.01.05.004; 07.05.04.004; 23.04.01.0060.000533%Not Available
Loss of consciousness17.02.04.0040.001066%Not Available
Lung disorder22.02.07.0010.004795%Not Available
Lymphadenopathy01.09.01.0020.000533%Not Available
Malaise08.01.01.0030.001598%
Mesothelioma16.39.01.001--Not Available
Metabolic acidosis14.01.01.0030.000533%Not Available
Metastases to liver09.04.02.004; 16.22.02.001--Not Available
Mood altered19.04.02.007--Not Available
Mood swings19.04.03.001--Not Available
Mouth ulceration07.05.06.0040.000533%Not Available
Mucosal inflammation08.01.06.0020.002131%Not Available
Muscular weakness15.05.06.001; 17.05.03.0050.000533%
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Myocardial ischaemia02.02.02.008; 24.04.04.010--Not Available
Nausea07.01.07.001--
Neoplasm malignant16.16.01.001--Not Available
Nephropathy20.05.03.001--Not Available
Nephropathy toxic20.05.03.002; 12.03.01.0100.001066%Not Available
Nervous system disorder17.02.10.001--Not Available
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.0040.004529%Not Available
Odynophagia07.05.03.001--Not Available
Oedema14.05.06.010; 08.01.07.0060.000799%Not Available
Oedema peripheral08.01.07.007; 02.05.04.007; 14.05.06.0110.001066%
Oesophagitis07.08.05.001--
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