Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pegvisomant
Drug ID BADD_D01699
Description Pegvisomant is a highly selective growth hormone (GH) receptor antagonist. It is used to treat acromegaly. Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), this drug actually blocks the hepatic (GH-mediated) production of insulin like growth factor (IGF-1), which is the main mediator of growth hormone activity.
Indications and Usage Pegvisomant is a growth hormone receptor antagonist used for the treatment of acromegaly.
Marketing Status Prescription
ATC Code H01AX01
DrugBank ID DB00082
KEGG ID D05394
MeSH ID C406545
PubChem ID Not Available
TTD Drug ID D0D6VE
NDC Product Code 0009-7168; 59267-9301; 59267-5376; 59267-9201; 0009-7199; 0009-7166; 0009-7200; 0009-7188; 59267-9401; 64052-001; 59267-5201
Synonyms pegvisomant | B2036-PEG | B-2036 PEG | Somavert
Chemical Information
Molecular Formula Not Available
CAS Registry Number 218620-50-9
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alanine aminotransferase increased13.03.01.003--
Aspartate aminotransferase increased13.03.01.006--
Back pain15.03.04.005--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Diarrhoea07.02.01.001--
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Hypertension24.08.02.001--
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Injection site reaction12.07.03.015; 08.02.03.014--
Injury12.01.08.004--Not Available
Liver function test abnormal13.03.01.013--Not Available
Nausea07.01.07.001--
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Pain08.01.08.004--
Paraesthesia17.02.06.005--
Sinusitis22.07.03.007; 11.01.13.005--
Transaminases increased13.03.01.015--Not Available
Antibody test positive13.06.03.001--Not Available
Lipohypertrophy23.07.01.005; 14.08.04.009--
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