Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Peginterferon beta-1a
Drug ID BADD_D01697
Description Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings.[L5801] MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792] Peginterferon beta-1a is an interferon therapy used for the management of relapsing forms of MS. It was originally approved by the FDA in 2014 for subcutaneous use, and was approved for intramuscular use in January 2021.[L31428] Currently, it is the only approved pegylated interferon for the management of MS with an proven ability to reduce relapses and delay the progression of disability resulting from MS.
Indications and Usage For the treatment of patients with relapsing forms of multiple sclerosis.
Marketing Status Prescription
ATC Code L03AB13
DrugBank ID DB09122
KEGG ID D10483
MeSH ID C428112
PubChem ID Not Available
TTD Drug ID D0LW4O
NDC Product Code 64406-012; 64406-016; 64406-015; 64406-011; 64406-017
Synonyms peginterferon beta-1a | polyethylene glycol-interferon-beta-1a | PEG IFN-beta-1a | polyethylene glycol-interferon beta-1a | Plegridy
Chemical Information
Molecular Formula Not Available
CAS Registry Number 1211327-92-2
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alanine aminotransferase increased13.03.01.003--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Body temperature increased13.15.01.001--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Chills08.01.09.001; 15.05.03.016--
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Depression19.15.01.001--
Gamma-glutamyltransferase increased13.03.01.011--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Hyperthermia08.05.01.001; 12.05.01.002--Not Available
Influenza like illness08.01.03.010--
Injection site erythema23.03.06.015; 12.07.03.001; 08.02.03.001--Not Available
Injection site haematoma24.07.01.009; 12.07.03.004; 08.02.03.004--Not Available
Injection site oedema12.07.03.024; 08.02.03.024--Not Available
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Injection site pruritus08.02.03.013; 23.03.12.007; 12.07.03.014--Not Available
Injection site rash23.03.13.010; 12.07.03.032; 08.02.03.032--Not Available
Injection site reaction12.07.03.015; 08.02.03.014--
Injection site warmth12.07.03.036; 08.02.03.036--Not Available
Myalgia15.05.02.001--
Nausea07.01.07.001--
Pain08.01.08.004--
Peripheral ischaemia24.04.03.002--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Seizure17.12.03.001--
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