Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pegaspargase
Drug ID BADD_D01692
Description Pegylated L-asparagine amidohydrolase from E. coli. Pegylation substantially (by a factor of 4) extends the protein half life.
Indications and Usage For treatment of acute lymphoblastic leukemia
Marketing Status Prescription
ATC Code L01XX24
DrugBank ID DB00059
KEGG ID D05387
MeSH ID C042705
PubChem ID 436058
TTD Drug ID D0U8JN
NDC Product Code 72694-954
Synonyms pegaspargase | pegylated asparaginase | polyethyleneglycol-asparaginase | PEG-asparaginase | pegylated-L-asparaginase | Oncaspar
Chemical Information
Molecular Formula C14H19NO
CAS Registry Number 130167-69-0
SMILES CC1=CC(=C(C=C1)C(=O)C(=C)CN(C)C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alanine aminotransferase increased13.03.01.003--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Aspartate aminotransferase increased13.03.01.006--
Bronchospasm22.03.01.004; 10.01.03.012--
Cerebral haemorrhage17.08.01.003; 24.07.04.001--Not Available
Cerebral thrombosis24.01.04.003; 17.08.01.006--Not Available
Coagulopathy01.01.02.001--Not Available
Death08.04.01.001--
Erythema23.03.06.001--Not Available
Hyperbilirubinaemia09.01.01.003; 01.06.04.003; 14.11.01.010--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Laryngeal oedema23.04.01.005; 22.04.02.001; 10.01.05.003--
Liver function test abnormal13.03.01.013--Not Available
Local swelling08.01.03.013--Not Available
Pancreatitis07.18.01.001--
Systemic lupus erythematosus rash23.03.13.007; 15.06.02.005; 10.04.03.005--Not Available
Thrombosis24.01.01.006--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Hypofibrinogenaemia01.01.01.010--Not Available
Transaminases increased13.03.01.015--Not Available
Neutralising antibodies13.06.03.010--Not Available
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