Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pazopanib
Drug ID BADD_D01687
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Indications and Usage Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Marketing Status approved
ATC Code L01EX03
DrugBank ID DB06589
KEGG ID D05380
MeSH ID C516667
PubChem ID 10113978
TTD Drug ID Not Available
NDC Product Code Not Available
UNII 7RN5DR86CK
Synonyms pazopanib | GW 786034B | GW786034B | GW-786034B | GW 780604 | GW780604 | GW-780604 | Votrient
Chemical Information
Molecular Formula C21H23N7O2S
CAS Registry Number 444731-52-6
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Leukopenia01.02.02.001--Not Available
Lipase increased13.05.01.003--
Liver disorder09.01.08.0010.006458%Not Available
Liver function test abnormal13.03.04.030--Not Available
Loss of consciousness17.02.04.004--Not Available
Lung disorder22.02.07.0010.001186%Not Available
Lung infiltration22.01.02.0040.000168%Not Available
Lymphopenia01.02.02.002--Not Available
Malaise08.01.01.0030.008876%
Mass08.03.05.0030.000739%Not Available
Melaena24.07.02.013; 07.12.02.004--Not Available
Memory impairment17.03.02.003; 19.20.01.0030.004130%
Meningioma17.20.01.005; 16.30.01.0050.000112%Not Available
Menopausal symptoms21.02.02.002--Not Available
Metastases to liver16.22.02.001; 09.04.02.0040.001287%Not Available
Metastases to lung22.08.01.005; 16.22.02.0020.003078%Not Available
Metastases to spine16.22.02.007; 15.09.03.0070.000336%Not Available
Mitral valve incompetence02.07.01.0020.000168%Not Available
Monoplegia17.01.04.0030.000168%Not Available
Mouth haemorrhage24.07.02.014; 07.05.02.0010.000358%
Mouth ulceration07.05.06.0040.000873%Not Available
Mucosal inflammation08.01.06.0020.002709%Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.0010.002395%
Musculoskeletal pain15.03.04.0070.002350%
Myalgia15.05.02.0010.007667%
Myocardial infarction24.04.04.009; 02.02.02.0070.002395%
Myocardial ischaemia24.04.04.010; 02.02.02.008--Not Available
Myopia06.02.04.0020.000246%Not Available
Myositis15.05.01.0010.000246%
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