Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pazopanib
Drug ID BADD_D01687
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Indications and Usage Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Marketing Status approved
ATC Code L01EX03
DrugBank ID DB06589
KEGG ID D05380
MeSH ID C516667
PubChem ID 10113978
TTD Drug ID Not Available
NDC Product Code Not Available
UNII 7RN5DR86CK
Synonyms pazopanib | GW 786034B | GW786034B | GW-786034B | GW 780604 | GW780604 | GW-780604 | Votrient
Chemical Information
Molecular Formula C21H23N7O2S
CAS Registry Number 444731-52-6
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Infestation23.11.01.002; 11.09.01.001--Not Available
Inflammation10.02.01.089; 08.01.05.0070.000504%Not Available
Limb discomfort15.03.04.0140.000526%Not Available
Intra-abdominal haemorrhage12.01.17.011; 24.07.02.035; 07.12.02.0080.000280%
Ischaemic stroke24.04.06.010; 17.08.01.018--Not Available
Malnutrition14.03.02.0040.000224%Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Metastatic neoplasm16.16.01.0070.000358%Not Available
Motor dysfunction17.01.02.031; 15.05.06.0060.000414%Not Available
Neoplasm progression16.16.02.0050.003156%Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.028251%
Gastrointestinal ulcer07.04.04.0020.000246%Not Available
Renal neoplasm20.01.04.004; 16.08.03.0010.000224%Not Available
Ill-defined disorder08.01.03.0490.000884%Not Available
Polyp16.02.02.005; 08.01.06.0100.000112%Not Available
Blood disorder01.05.01.0040.000168%Not Available
Disease progression08.01.03.0380.019632%
Drug intolerance08.06.01.013--Not Available
Hepatic lesion09.01.08.0050.000224%Not Available
Hepatobiliary disease09.01.08.003--Not Available
Lung neoplasm16.19.04.001; 22.08.01.0060.000168%Not Available
Pigmentation disorder23.05.03.0010.000548%Not Available
Metastasis16.22.01.0010.000783%Not Available
Microangiopathy24.03.02.0210.000112%Not Available
Renal impairment20.01.03.0100.003716%Not Available
Hypophagia19.09.01.004; 14.03.01.006; 07.01.06.0100.000448%Not Available
Tumour invasion16.16.01.0080.000168%Not Available
Exfoliative rash23.03.07.006--Not Available
Osteonecrosis of jaw24.04.05.005; 15.02.04.0100.000560%
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