Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pazopanib
Drug ID BADD_D01687
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Indications and Usage Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Marketing Status approved
ATC Code L01EX03
DrugBank ID DB06589
KEGG ID D05380
MeSH ID C516667
PubChem ID 10113978
TTD Drug ID Not Available
NDC Product Code Not Available
UNII 7RN5DR86CK
Synonyms pazopanib | GW 786034B | GW786034B | GW-786034B | GW 780604 | GW780604 | GW-780604 | Votrient
Chemical Information
Molecular Formula C21H23N7O2S
CAS Registry Number 444731-52-6
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Paraesthesia23.03.03.094; 17.02.06.005--
Peptic ulcer07.04.07.0010.000112%Not Available
Pericardial effusion02.06.01.0020.000448%
Peripheral coldness23.06.04.008; 24.04.03.006; 08.01.09.0100.000302%Not Available
Peripheral sensory neuropathy17.09.03.005--
Peripheral vascular disorder24.03.01.0030.000246%Not Available
Peritonitis11.01.07.007; 07.19.05.004--
Peroneal nerve palsy17.09.02.0030.000381%Not Available
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.0020.000302%Not Available
Pharyngeal ulceration22.04.05.0040.000112%Not Available
Photosensitivity reaction23.03.09.003--
Platelet count decreased13.01.04.001--
Pleural effusion22.05.02.0020.003033%
Pneumothorax22.05.02.0030.003571%
Polycythaemia01.07.01.0010.000168%Not Available
Polyneuropathy17.09.03.0120.000168%Not Available
Proctalgia07.03.02.0010.000246%
Productive cough22.02.03.0050.000716%
Proteinuria20.02.01.0110.004298%
Prurigo23.03.04.017--Not Available
Pruritus23.03.12.001--
Pulmonary congestion24.03.08.001; 22.01.03.002; 02.05.02.0020.000739%Not Available
Pulmonary embolism22.06.02.001; 24.01.06.001--Not Available
Pulmonary haemorrhage22.12.01.009; 24.07.01.0160.000168%
Purpura23.06.01.004; 24.07.06.005; 01.01.04.0030.000336%
Pyoderma gangrenosum10.04.02.009; 23.07.03.001; 16.32.03.0050.000224%Not Available
Pyrexia08.05.02.0030.005484%
Rash23.03.13.001--Not Available
Rash erythematous23.03.13.029--Not Available
Rash macular23.03.13.0030.001119%Not Available
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