| Drug Name |
Paroxetine hydrochloride |
| Drug ID |
BADD_D01680 |
| Description |
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others.[T653] It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters.[A31914] Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class.[A31914] The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742] |
| Indications and Usage |
Labeled indications include: major depressive disorder (MDD), panic disorder with or without agoraphobia, obsessive-compulsive disorder (OCD), social anxiety disorder (social phobia), generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). Unlabeled indications include: eating disorders, impulse control disorders, vasomotor symptoms of menopause, obsessive-compulsive disorder (OCD) in children, and mild dementia-associated agitation in nonpsychotic individuals. Brisdelle, which consists of paroxetine mesylate is indicated for the treatment of moderate to severe vasomotor symptoms (like hot flashes) associated with menopause. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
N06AB05 |
| DrugBank ID |
DB00715
|
| KEGG ID |
D05374
|
| MeSH ID |
D017374
|
| PubChem ID |
62878
|
| TTD Drug ID |
D06GDY
|
| NDC Product Code |
65862-154; 67544-492; 61187-005; 65841-099; 60429-735; 68084-046; 68788-0797; 0904-5678; 16714-182; 60505-4377; 60505-3675; 60505-0101; 60505-0402; 70518-0993; 50090-0849; 65841-097; 60505-4519; 68084-047; 0904-5679; 60505-4517; 65841-601; 43353-845; 69986-011; 50090-0922; 60505-4518; 0904-5676; 68084-044; 68071-4323; 50090-5566; 60505-3670; 60505-4379; 60429-734; 71335-0572; 60505-0097; 60505-1316; 68084-045; 60505-0084; 68788-9074; 70518-1460; 60505-4520; 60429-737; 60505-1318; 65841-098; 65862-156; 60505-4378; 60505-1317; 62175-470; 16714-183; 67544-317; 68071-4283; 43353-994; 0904-5677; 65862-155; 60505-3674; 70518-2118; 60505-0083; 71335-1882; 62175-472; 49999-632; 63629-8527; 65862-157; 71610-348; 50090-1296; 70518-2871; 16714-181; 69986-012; 16714-184; 55154-7999; 60505-3673; 71335-1205; 62175-471; 60505-3669; 60429-736 |
| Synonyms |
Paroxetine | Aropax | BRL-29060 | BRL 29060 | BRL29060 | FG-7051 | FG 7051 | FG7051 | Paroxetine Acetate | Seroxat | Paroxetine Hydrochloride Anhydrous | Paroxetine Maleate | Paroxetine, cis-(+)-Isomer | Paroxetine, cis-(-)-Isomer | Paroxetine, trans-(+)-Isomer | Paxil | Paroxetine Hydrochloride Hemihydrate | Paroxetine Hydrochloride, Hemihydrate | Paroxetine Hydrochloride |
