| Pharmaceutical Information |
| Drug Name |
Parecoxib |
| Drug ID |
BADD_D01674 |
| Description |
Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States. A letter of non-approval for parecoxib was issued by the FDA in 2005. |
| Indications and Usage |
Used for short term perioperative pain control. |
| Marketing Status |
Not Available |
| ATC Code |
M01AH04 |
| DrugBank ID |
DB08439
|
| KEGG ID |
D03716
|
| MeSH ID |
C409945
|
| PubChem ID |
119828
|
| TTD Drug ID |
D05UWI
|
| NDC Product Code |
Not Available |
| Synonyms |
parecoxib | N-(((5-methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamide | N-(((Me-P)-P)S)P | parecoxib sodium | N-(((5-methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamine, sodium salt | Dynastat |
|
| Chemical Information |
| Molecular Formula |
C19H18N2O4S |
| CAS Registry Number |
198470-84-7 |
| SMILES |
CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
| Acute kidney injury | 20.01.03.016 | - | - | |
|
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