Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Panitumumab
Drug ID BADD_D01666
Description Panitumumab (ABX-EGF) is a recombinant human IgG2 monoclonal antibody that binds specifically to the human epidermal growth factor receptor (EGFR). This drug is an antineoplastic agent. Panitumumab was granted FDA approval on 27 September 2006.[L17663]
Indications and Usage For the treatment of EGFR-expressing, metastatic colorectal carcinoma that is refractory to fluoropyrimidine-, oxaliplatin-, and irinotecan- containing chemotherapy regimens.
Marketing Status Prescription
ATC Code L01FE02
DrugBank ID DB01269
KEGG ID D05350
MeSH ID D000077544
PubChem ID Not Available
TTD Drug ID D0HU9H
NDC Product Code 55513-954; 55513-956
Synonyms Panitumumab | Panitumumab Antibody, Human | Human Panitumumab Antibody | ABX-EGF MAb | ABX-EGF Monoclonal Antibody | ABX EGF Monoclonal Antibody | Monoclonal Antibody, ABX-EGF | Vectibix
Chemical Information
Molecular Formula Not Available
CAS Registry Number 339177-26-3
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Paronychia23.09.04.001; 11.01.12.001--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Sepsis11.01.11.003--
Skin exfoliation23.03.07.003--Not Available
Skin fissures23.03.03.008--Not Available
Skin necrosis23.03.03.011--Not Available
Stomatitis07.05.06.005--
Vomiting07.01.07.003--
Growth of eyelashes06.06.04.007--Not Available
General physical health deterioration08.01.03.018--Not Available
Eyelid irritation06.04.04.007; 23.03.04.023--Not Available
Skin toxicity23.03.03.032; 12.03.01.020--Not Available
Antibody test13.06.03.009--Not Available
Ocular toxicity12.03.01.031; 06.11.01.006--Not Available
Ulcerative keratitis06.04.02.004; 10.02.01.021--
Toxicity to various agents12.03.01.046--Not Available
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