Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Paclitaxel
Drug ID BADD_D01653
Description Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intravenous solution for injection and the newer formulation contains albumin-bound paclitaxel marketed under the brand name Abraxane.
Indications and Usage Used in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane® is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer.
Marketing Status Prescription; Discontinued
ATC Code L01CD01
DrugBank ID DB01229
KEGG ID D00491
MeSH ID D017239
PubChem ID 36314
TTD Drug ID D0C4RB
NDC Product Code 52222-0001; 63126-902; 69539-159; 45963-613; 63323-763; 16714-137; 47781-595; 68817-134; 42533-111; 68083-179; 72205-062; 60505-6230; 70860-215; 72205-061; 68083-178; 49452-4961; 44567-506; 70747-1003; 69539-158; 0703-3216; 68554-0061; 0703-3218; 65129-1308; 51446-0110; 68001-516; 17359-3055; 69443-022; 0703-3217; 17359-4040; 44567-504; 0703-4768; 0703-3213; 69539-157; 61703-342; 65129-2039; 54893-0007; 24979-710; 70860-200; 44567-505; 62422-0002; 59651-605; 72205-063; 68083-180; 51446-0120; 0703-4764; 17359-4055
Synonyms Paclitaxel | Anzatax | NSC-125973 | NSC 125973 | NSC125973 | Taxol | Taxol A | Bris Taxol | Taxol, Bris | Paclitaxel, (4 alpha)-Isomer | Paxene | Praxel | 7-epi-Taxol | 7 epi Taxol | Onxol
Chemical Information
Molecular Formula C47H51NO14
CAS Registry Number 33069-62-4
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6) O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ApoptosisPoly [ADP-ribose] polymerase 1Q9ZP54Not Available10516758; 12522001; 11961058; 9783732
ApoptosisDolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1P61803Not Available10962577; 11077039; 10832593; 10962577; 15905586; 10815922; 11880364
ApoptosisProto-oncogene serine/threonine-protein kinase mosP00540Not Available9721872; 9668078; 9506539
ApoptosisBaculoviral IAP repeat-containing protein 3Q13489T3517310962577; 15905586; 10815922; 11880364
ApoptosisGlutathione S-transferase PP04906Not Available9721872; 9668078; 9506539
ApoptosisSuperoxide dismutaseQ4ZJI1Not Available10962577; 15905586; 10815922; 11880364; 10962577; 11077039; 10832593
ApoptosisLipoprotein lipaseP06858T2869225891676
ApoptosisBcl2-associated agonist of cell deathQ92934Not Available10516758; 12522001; 11961058; 9783732
ApoptosisMitogen-activated protein kinase 1P28482T589709721872; 9668078; 9506539
ApoptosisTNF receptor-associated factor 1Q13077Not Available10962577; 15905586; 10815922; 11880364
Apoptosisvon Willebrand factorP04275T2334825891676
ApoptosisBaculoviral IAP repeat-containing protein 2Q13490T8478010962577; 11077039; 10832593
ApoptosisAlkaline phosphatase, tissue-nonspecific isozymeP05186T0953825891676
ApoptosisCyclin-dependent kinase 20Q8IZL9Not Available9865921; 8909543; 15604277
ApoptosisNuclear factor NF-kappa-B p105 subunitP19838T4019210962577; 11077039; 10832593; 10962577; 15905586; 10815922; 11880364
Cytogenetic abnormalityCellular tumor antigen p53P04637T1573912897130; 15657900; 15590693
Cytogenetic abnormalitySerine/threonine-protein kinase PLK2Q9NYY3T5965412897130; 15657900; 15590693
Cytogenetic abnormalityCyclin-dependent kinase 20Q8IZL9Not Available9865921; 8909543; 15604277
Impaired healingLipoprotein lipaseP06858T2869225891676
Impaired healingAlkaline phosphatase, tissue-nonspecific isozymeP05186T0953825891676
Impaired healingvon Willebrand factorP04275T2334825891676
Mitochondrial toxicityPoly [ADP-ribose] polymerase 1Q9ZP54Not Available10516758; 12522001; 11961058; 9783732
Vascular disordersAlkaline phosphatase, tissue-nonspecific isozymeP05186T0953825891676
Vascular disordersvon Willebrand factorP04275T2334825891676
Vascular disordersLipoprotein lipaseP06858T2869225891676
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Circulatory collapse24.06.02.0010.001865%Not Available
Clonus17.02.05.0020.001332%Not Available
Clostridium difficile colitis11.02.02.004; 07.19.01.0040.000533%Not Available
Cold sweat23.02.03.002; 08.01.03.0240.003730%Not Available
Colitis07.08.01.0010.001598%
Colitis ischaemic24.04.08.012; 07.08.01.004--Not Available
Coma17.02.09.001--Not Available
Complications of transplanted heart12.02.09.013; 02.01.01.012--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis06.04.01.002; 11.01.06.0120.000799%
Constipation07.02.02.001--
Coronary artery stenosis24.04.04.017; 02.02.01.010--Not Available
Cough22.02.03.0010.022379%
Cryptosporidiosis infection11.06.02.001; 07.19.03.002--Not Available
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.0020.010390%
Cyst08.03.05.001; 16.02.02.002--Not Available
Cystitis11.01.14.001; 20.03.02.0020.001598%
Cystitis haemorrhagic20.03.02.0030.001066%Not Available
Deafness04.02.01.0010.001865%Not Available
Deafness neurosensory17.04.07.001; 04.02.01.002--Not Available
Death08.04.01.0010.063661%
Defaecation urgency07.02.04.0010.001865%Not Available
Dehydration14.05.05.001--
Delirium19.13.02.001--
Depressed level of consciousness17.02.04.002--
Depressed mood19.15.02.001--Not Available
Depression19.15.01.001--
Dermatitis23.03.04.0020.001598%Not Available
Dermatitis atopic23.03.04.016; 10.01.04.004--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
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