Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Paclitaxel
Drug ID BADD_D01653
Description Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intravenous solution for injection and the newer formulation contains albumin-bound paclitaxel marketed under the brand name Abraxane.
Indications and Usage Used in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane® is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer.
Marketing Status Prescription; Discontinued
ATC Code L01CD01
DrugBank ID DB01229
KEGG ID D00491
MeSH ID D017239
PubChem ID 36314
TTD Drug ID D0C4RB
NDC Product Code 52222-0001; 63126-902; 69539-159; 45963-613; 63323-763; 16714-137; 47781-595; 68817-134; 42533-111; 68083-179; 72205-062; 60505-6230; 70860-215; 72205-061; 68083-178; 49452-4961; 44567-506; 70747-1003; 69539-158; 0703-3216; 68554-0061; 0703-3218; 65129-1308; 51446-0110; 68001-516; 17359-3055; 69443-022; 0703-3217; 17359-4040; 44567-504; 0703-4768; 0703-3213; 69539-157; 61703-342; 65129-2039; 54893-0007; 24979-710; 70860-200; 44567-505; 62422-0002; 59651-605; 72205-063; 68083-180; 51446-0120; 0703-4764; 17359-4055
Synonyms Paclitaxel | Anzatax | NSC-125973 | NSC 125973 | NSC125973 | Taxol | Taxol A | Bris Taxol | Taxol, Bris | Paclitaxel, (4 alpha)-Isomer | Paxene | Praxel | 7-epi-Taxol | 7 epi Taxol | Onxol
Chemical Information
Molecular Formula C47H51NO14
CAS Registry Number 33069-62-4
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6) O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ApoptosisGlutathione S-transferase PP04906Not Available9721872; 9668078; 9506539
ApoptosisSuperoxide dismutaseQ4ZJI1Not Available10962577; 15905586; 10815922; 11880364; 10962577; 11077039; 10832593
ApoptosisLipoprotein lipaseP06858T2869225891676
ApoptosisBcl2-associated agonist of cell deathQ92934Not Available10516758; 12522001; 11961058; 9783732
ApoptosisMitogen-activated protein kinase 1P28482T589709721872; 9668078; 9506539
ApoptosisTNF receptor-associated factor 1Q13077Not Available10962577; 15905586; 10815922; 11880364
Apoptosisvon Willebrand factorP04275T2334825891676
ApoptosisBaculoviral IAP repeat-containing protein 2Q13490T8478010962577; 11077039; 10832593
ApoptosisAlkaline phosphatase, tissue-nonspecific isozymeP05186T0953825891676
ApoptosisCyclin-dependent kinase 20Q8IZL9Not Available9865921; 8909543; 15604277
ApoptosisNuclear factor NF-kappa-B p105 subunitP19838T4019210962577; 11077039; 10832593; 10962577; 15905586; 10815922; 11880364
ApoptosisPoly [ADP-ribose] polymerase 1Q9ZP54Not Available10516758; 12522001; 11961058; 9783732
ApoptosisDolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1P61803Not Available10962577; 11077039; 10832593; 10962577; 15905586; 10815922; 11880364
ApoptosisProto-oncogene serine/threonine-protein kinase mosP00540Not Available9721872; 9668078; 9506539
ApoptosisBaculoviral IAP repeat-containing protein 3Q13489T3517310962577; 15905586; 10815922; 11880364
Cytogenetic abnormalitySerine/threonine-protein kinase PLK2Q9NYY3T5965412897130; 15657900; 15590693
Cytogenetic abnormalityCyclin-dependent kinase 20Q8IZL9Not Available9865921; 8909543; 15604277
Cytogenetic abnormalityCellular tumor antigen p53P04637T1573912897130; 15657900; 15590693
Impaired healingAlkaline phosphatase, tissue-nonspecific isozymeP05186T0953825891676
Impaired healingvon Willebrand factorP04275T2334825891676
Impaired healingLipoprotein lipaseP06858T2869225891676
Mitochondrial toxicityPoly [ADP-ribose] polymerase 1Q9ZP54Not Available10516758; 12522001; 11961058; 9783732
Vascular disordersvon Willebrand factorP04275T2334825891676
Vascular disordersLipoprotein lipaseP06858T2869225891676
Vascular disordersAlkaline phosphatase, tissue-nonspecific isozymeP05186T0953825891676
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bladder cancer20.03.04.001; 16.08.01.001--Not Available
Blindness06.02.02.001; 17.17.01.003--Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Blood albumin decreased13.09.01.0010.000533%Not Available
Blood bilirubin increased13.03.01.0080.003730%
Blood creatinine increased13.13.01.004--
Blood glucose decreased13.02.02.001--Not Available
Blood glucose increased13.02.02.002--Not Available
Blood lactate dehydrogenase increased13.04.02.0020.000799%
Blood magnesium decreased13.11.01.0080.001332%Not Available
Blood potassium decreased13.11.01.0100.002398%Not Available
Blood pressure abnormal13.14.03.0010.001598%Not Available
Blood pressure decreased13.14.03.0020.005328%Not Available
Blood pressure increased13.14.03.005--Not Available
Blood pressure systolic decreased13.14.03.007--Not Available
Blood pressure systolic increased13.14.03.0060.001598%Not Available
Blood sodium decreased13.11.01.012--Not Available
Blood urea decreased13.13.01.0170.000533%Not Available
Body temperature increased13.15.01.0010.001066%Not Available
Bone disorder15.02.04.004--Not Available
Bone pain15.02.01.0010.003996%
Bradycardia02.03.02.002--Not Available
Breast cancer21.05.01.003; 16.10.01.0010.002015%Not Available
Breast cancer stage IV21.05.01.010; 16.10.01.003--Not Available
Breast pain21.05.05.003--
Bronchial obstruction22.03.01.0130.000799%
Bronchiectasis22.03.02.0050.000533%Not Available
Bronchitis11.01.09.001; 22.07.01.001--
Bronchospasm22.03.01.004; 10.01.03.0120.014653%
Bronchostenosis22.03.01.0200.001332%
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