Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Paclitaxel
Drug ID BADD_D01653
Description Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intravenous solution for injection and the newer formulation contains albumin-bound paclitaxel marketed under the brand name Abraxane.
Indications and Usage Used in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane® is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer.
Marketing Status approved; vet_approved
ATC Code L01CD01
DrugBank ID DB01229
KEGG ID D00491
MeSH ID D017239
PubChem ID 36314
TTD Drug ID D0C4RB
NDC Product Code 0703-3213; 52222-0001; 65129-1308; 68083-179; 69539-159; 62422-0004; 68001-516; 68083-178; 0703-4768; 68554-0061; 46708-622; 47781-595; 62332-621; 62332-622; 63323-763; 72205-063; 60505-6230; 62332-620; 72205-062; 0517-4300; 0703-3216; 0703-3218; 17359-3055; 63126-902; 69539-158; 72205-061; 17359-4056; 49452-4961; 51446-0110; 59651-605; 0703-4764; 51446-0120; 46708-620; 61703-342; 68083-180; 0703-3217; 17359-4040; 62422-0002; 69539-157; 70860-215; 42533-111; 54893-0007; 65129-2039; 69443-022; 16714-137; 68817-134; 70860-200; 17359-4055; 65892-002; 24979-710; 46708-621
UNII P88XT4IS4D
Synonyms Paclitaxel | Anzatax | NSC-125973 | NSC 125973 | NSC125973 | Taxol | Taxol A | Bris Taxol | Taxol, Bris | Paclitaxel, (4 alpha)-Isomer | Paxene | Praxel | 7-epi-Taxol | 7 epi Taxol | Onxol
Chemical Information
Molecular Formula C47H51NO14
CAS Registry Number 33069-62-4
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6) O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.004--Not Available
Bone pain15.02.01.0010.001332%
Bradycardia02.03.02.002--Not Available
Bradypnoea22.02.01.0020.000112%Not Available
Breast cancer21.05.01.003; 16.10.01.0010.002753%Not Available
Breast cancer stage IV21.05.01.010; 16.10.01.003--Not Available
Breast pain21.05.05.003--
Bronchial obstruction22.03.01.0130.000168%
Bronchiectasis22.03.02.0050.000112%Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm10.01.03.012; 22.03.01.0040.005171%
Bronchostenosis22.03.01.0200.000504%
Bundle branch block left02.03.01.0070.000280%Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Cachexia16.32.03.011; 14.03.02.001; 08.01.01.0090.000280%Not Available
Capillary leak syndrome08.01.07.012; 24.06.03.0010.000224%
Cardiac arrest02.03.04.0010.002295%
Cardiac failure02.05.01.001--
Cardiac failure acute02.05.01.0050.000224%Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.002988%Not Available
Cardiomyopathy02.04.01.0010.000526%Not Available
Cardiovascular disorder02.11.01.010; 24.03.02.009--Not Available
Cellulitis23.11.02.004; 11.02.01.001--Not Available
Cerebellar syndrome17.02.02.0020.000168%Not Available
Cerebral artery embolism24.01.04.001; 17.08.01.0010.000168%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Cervix carcinoma16.12.01.001; 21.06.02.0010.000112%Not Available
Chest discomfort22.12.02.002; 08.01.08.019; 02.02.02.0090.014551%Not Available
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ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene