Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Oxtriphylline
Drug ID BADD_D01642
Description Oxtriphylline is the choline salt form of [theophylline]. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Its main physiological reponse is to dilate the bronchioles. As such, oxytriphylline is indicated mainly for asthma, bronchospasm, and COPD (i.e. all the same indications as the other theophyllines). It is marketed under the name Choledyl SA, and several forms of oxytriphylline have been discontinued. In the US, oxtriphylline is no longer available.
Indications and Usage Used to treat the symptoms of asthma, bronchitis, COPD, and emphysema.
Marketing Status Prescription; Discontinued
ATC Code R03DA02
DrugBank ID DB01303
KEGG ID D02017
MeSH ID C012839
PubChem ID 656652
TTD Drug ID D0B0SH
NDC Product Code Not Available
Synonyms cholinophyllin | oxtriphylline | choline theophyllinate | cholinetheophyllinate | Brondecon | Theobret | Choledyl-SA | Euspirax | oxtripylline-SA | Brondaxin | Choledyl
Chemical Information
Molecular Formula C12H21N5O3
CAS Registry Number 4499-40-5
SMILES CN1C(=C2C(=NC=N2)N(C1=O)C)[O-].C[N+](C)(C)CCO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Tachycardia02.03.02.007--Not Available
Tachypnoea22.02.01.014--Not Available
Tension19.06.02.005--Not Available
Thrombocytopenia01.08.01.002--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Ventricular arrhythmia02.03.04.006--
Vomiting07.01.07.003--
Pruritus generalised23.03.12.003--Not Available
Inappropriate antidiuretic hormone secretion14.05.07.001; 05.03.03.001--Not Available
Intestinal haemorrhage24.07.02.031; 07.12.03.005--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
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