Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Oxcarbazepine
Drug ID BADD_D01637
Description Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L863] It is a structural derivative of [carbamazepine][A186101] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate in the blood - a pro-drug of the more active (S)-enantiomer is also marketed as a separate anti-epileptic under the name [eslicarbazepine].[A186011] Compared to other anti-epileptic drugs, which are generally metabolized via the cytochrome P450 system, oxcarbazepine has a reduced propensity for involvement in drug-drug interactions owing to its primarily reductive metabolism.[A186032]
Indications and Usage For use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults with epilepsy and as adjunctive therapy in the treatment of partial seizures in children ages 4-16 with epilepsy.
Marketing Status Prescription; Discontinued
ATC Code N03AF02
DrugBank ID DB00776
KEGG ID D00533
MeSH ID D000078330
PubChem ID 34312
TTD Drug ID D0QL3P
NDC Product Code 55289-007; 76047-001; 48087-0115; 71335-0144; 31722-023; 82334-001; 48087-0046; 68084-867; 48087-0158; 55512-0018; 50268-649; 55154-8198; 66406-0246; 63629-3816; 68462-137; 70518-1842; 50090-5003; 66406-0245; 65372-1104; 51991-293; 51508-008; 51991-292; 51672-4105; 68084-845; 70518-2253; 71428-007; 55512-0017; 70518-2377; 70518-2276; 51672-4106; 71335-0505; 55154-8187; 17772-122; 50383-312; 68084-853; 58159-088; 60429-061; 70518-3237; 72189-339; 55512-0006; 0615-8292; 66406-0244; 70518-3127; 68788-7866; 68462-138; 17772-123; 51672-4107; 63629-2075; 0615-8153; 48087-0118; 68462-139; 31722-025; 48087-0157; 66039-905; 0078-0456; 69766-055; 55512-0008; 70518-1027; 70518-0894; 0781-6270; 71205-411; 70518-1055; 42419-006; 0078-0457; 48087-0114; 71335-0090; 62756-183; 0078-0337; 70518-2254; 60429-062; 62512-0058; 31722-024; 55512-0023; 55512-0016; 68094-123; 55700-868; 60429-063; 51991-294; 72761-033; 0054-0199; 55512-0007; 63629-4987; 63629-6834; 42419-029; 70518-2370; 17772-121; 62756-185; 0078-0357; 70966-0004; 62756-184; 70518-1980; 70518-3197; 12658-0588; 65162-649
Synonyms Oxcarbazepine | 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide | Trileptal | Timox | GP 47680
Chemical Information
Molecular Formula C15H12N2O2
CAS Registry Number 28721-07-5
SMILES C1C2=CC=CC=C2N(C3=CC=CC=C3C1=O)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Libido decreased21.03.02.005; 19.08.03.001--
Libido increased19.08.03.002; 21.03.02.007--
Ligament sprain15.07.02.004; 12.01.07.008--Not Available
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.0050.000831%Not Available
Lip ulceration07.05.01.0060.000831%Not Available
Lipase increased13.05.01.0030.000831%
Liver function test abnormal13.03.01.0130.001247%Not Available
Loss of consciousness17.02.04.0040.005402%Not Available
Lower respiratory tract infection22.07.01.002; 11.01.09.002--Not Available
Lung disorder22.02.07.0010.000325%Not Available
Lymphadenopathy01.09.01.0020.001247%Not Available
Lymphocytosis01.02.01.0030.000831%Not Available
Malabsorption14.02.01.004; 07.17.01.0010.002078%
Malaise08.01.01.0030.010805%
Mania19.16.02.0020.000831%
Memory impairment19.20.01.003; 17.03.02.0030.006649%
Menopausal symptoms21.02.02.002--Not Available
Menorrhagia21.01.03.002--
Mental disability26.01.01.001--Not Available
Mental impairment19.21.02.003; 17.03.03.002--Not Available
Metrorrhagia21.01.01.0060.000831%Not Available
Microcephaly15.11.02.002; 03.11.02.0020.000831%Not Available
Migraine17.14.02.001; 24.03.05.003--Not Available
Miliaria23.02.03.014--Not Available
Mood altered19.04.02.0070.001247%Not Available
Mood swings19.04.03.001--Not Available
Mouth ulceration07.05.06.0040.000831%Not Available
Movement disorder17.01.02.0100.002078%Not Available
Mucosal inflammation08.01.06.0020.000831%Not Available
Multiple fractures15.08.02.005; 12.04.02.009--Not Available
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