Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Oxazepam
Drug ID BADD_D01636
Description Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feature is advantageous as compared to other benzodiazepines, and is likely owing in part to oxazepam's relatively simple metabolism.[A203516] It is an active metabolite of both [diazepam] and [temazepam][A39486] and undergoes very little biotransformation following absorption, making it unlikely to participate in pharmacokinetic interactions.[L13895]
Indications and Usage For the treatment of anxiety disorders and alcohol withdrawal.
Marketing Status Prescription; Discontinued
ATC Code N05BA04
DrugBank ID DB00842
KEGG ID D00464
MeSH ID D010076
PubChem ID 4616
TTD Drug ID D09LDR
NDC Product Code 62584-812; 43353-965; 62584-813; 0228-2067; 72166-009; 64330-015; 0228-2069; 67544-117; 71610-639; 0228-2073; 43353-980; 48087-0087; 62584-814; 12828-0024; 52817-292; 52817-290; 52817-291; 67544-268
Synonyms Oxazepam | Serax | Tazepam | Adumbran
Chemical Information
Molecular Formula C15H11ClN2O2
CAS Registry Number 604-75-1
SMILES C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.010449%Not Available
Abdominal pain07.01.05.0020.006966%
Abdominal pain upper07.01.05.0030.006966%
Aggression19.05.01.0010.013932%Not Available
Agitation17.02.05.012; 19.06.02.0010.013932%
Agranulocytosis01.02.03.001--Not Available
Akathisia19.06.02.006; 17.01.02.0020.010449%
Amnesia19.20.01.001; 17.03.02.001--
Anger19.04.02.0010.006966%Not Available
Anxiety19.06.02.0020.013932%
Aspartate aminotransferase increased13.03.01.0060.010449%
Asphyxia22.02.02.001; 12.01.08.0110.009994%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.006966%Not Available
Bradypnoea22.02.01.0020.010449%Not Available
Cardiac arrest02.03.04.0010.003634%
Coma17.02.09.0010.038312%Not Available
Completed suicide08.04.01.010; 19.12.01.0010.002726%Not Available
Confusional state19.13.01.001; 17.02.03.0050.031346%
Constipation07.02.02.0010.010449%
Death08.04.01.001--
Delirium19.13.02.0010.013932%
Depressed level of consciousness17.02.04.0020.020897%
Depression19.15.01.0010.010449%
Dermatitis23.03.04.002--Not Available
Diplopia17.17.01.005; 06.02.06.002--Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Disturbance in attention19.21.02.002; 17.03.03.0010.010449%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.020897%
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