Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Omeprazole
Drug ID BADD_D01614
Description Originally approved by the FDA in 1989, omeprazole is a _proton-pump inhibitor_, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class, and its approval was followed by the formulation of many other proton pump inhibitor drugs [A174232]. Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults [FDA label].
Indications and Usage Omeprazole, according to the FDA label [FDA label] is a proton pump inhibitor (PPI) used for the following purposes: • Treatment of active duodenal ulcer in adults • Eradication of Helicobacter pylori to reduce the risk of duodenal ulcer recurrence in adults • Treatment of active benign gastric ulcer in adults • Treatment of symptomatic gastroesophageal reflux disease (GERD) in patients 1 year of age and older • Treatment of erosive esophagitis (EE) due to acid-mediated GERD in patients 1 month of age and older • Maintenance of healing of EE due to acid-mediated GERD in patients 1 year of age and older • Pathologic hypersecretory conditions in adults
Marketing Status approved; investigational; vet_approved
ATC Code A02BC01
DrugBank ID DB00338
KEGG ID D00455
MeSH ID D009853
PubChem ID 4594
TTD Drug ID D01XNB
NDC Product Code 81522-915; 82009-022; 82009-023; 38779-1935; 66174-0013; 21130-128; 30142-394; 43598-286; 43598-841; 49035-119; 50268-620; 53943-016; 55910-915; 59640-047; 60505-0065; 61919-807; 63187-828; 63941-006; 65841-761; 68016-759; 68462-395; 69842-941; 70518-3368; 71205-960; 71335-1639; 72288-401; 72288-915; 72789-257; 80425-0109; 42765-010; 59651-003; 11822-0061; 16714-714; 0113-7520; 41250-349; 42708-158; 49348-846; 50090-3876; 50268-619; 50268-656; 51407-130; 51407-287; 51660-061; 55910-215; 57237-160; 58602-729; 59779-503; 0363-0915; 62756-377; 0363-1607; 63629-8108; 65841-759; 65841-760; 67091-316; 70677-0148; 0536-1322; 71335-1746; 71610-248; 72789-155; 0781-2234; 76162-470; 79903-113; 80425-0071; 11722-053; 51927-3445; 59651-050; 65862-395; 71747-001; 11673-346; 11822-0453; 16714-123; 16714-715; 21130-137; 30142-992; 0113-1803; 37835-189; 41163-915; 41250-915; 41520-802; 46122-616; 55111-645; 55910-712; 57896-960; 59651-002; 59779-580; 60505-0145; 0363-1008; 63187-170; 0363-1819; 63187-820; 63868-471; 68071-2893; 68071-3007; 68391-915; 70518-2791; 70518-3278; 70934-015; 71205-157; 0615-8079; 72036-981; 72288-047; 55681-306; 55910-713; 56062-915; 58602-850; 62135-530; 64380-183; 67296-0706; 67296-1367; 68071-2199; 69256-915; 69618-054; 70000-0521; 70934-994; 71205-959; 71335-1636; 71610-663; 0615-8406; 80425-0070; 63850-3153; 65628-070; 37808-354; 37808-401; 37808-915; 41163-634; 41520-939; 42708-170; 45802-888; 45865-966; 49035-983; 50594-011; 51407-303; 51655-452; 53002-2688; 55154-2332; 58602-826; 58602-837; 60760-868; 61919-847; 68071-2432; 68382-411; 68382-412; 68788-6881; 68788-7626; 71205-501; 71335-0332; 72476-473; 80136-852; 61876-0724; 66603-704; 0113-7401; 0113-7915; 46122-029; 50090-5901; 51316-061; 53002-1688; 57237-162; 59651-001; 62175-136; 68071-2243; 68462-396; 70000-0381; 70518-0199; 71335-1532; 71713-301; 0781-2785; 0904-5834; 51552-1050; 53104-7520; 10202-722; 62207-983; 65129-3069; 73476-644; 16714-634; 30142-557; 0113-0520; 0113-1723; 36800-915; 43063-743; 50090-2769; 55111-643; 55111-644; 55301-915; 55319-037; 56062-401; 60505-0146; 0363-0007; 62175-118; 63187-061; 68071-2262; 68196-915; 68382-500; 68462-397; 68788-6995; 70518-2235; 70700-150; 71335-0559; 71335-0569; 71335-1852; 71610-280; 71610-704; 0781-2859; 0781-2868; 79481-0075; 38779-3183; 62991-2400; 66039-922; 73476-643; 30142-077; 41520-915; 49999-265; 51407-256; 51407-816; 51660-029; 60505-3952; 60687-608; 62175-114; 63187-787; 63940-242; 68071-1943; 68071-2688; 68071-2741; 68196-303; 69230-318; 69842-791; 70518-2295; 71335-0490; 71335-1851; 71335-9744; 71610-688; 76420-055; 79481-0061; 49452-4891; 51927-0055; 51991-995; 53069-0260; 60592-508; 65977-0041; 75945-234; 21130-018; 0113-0915; 42708-159; 51407-129; 55111-158; 55154-8191; 55700-410; 57237-161; 62011-0157; 63187-070; 63187-805; 68001-441; 68071-2655; 68084-128; 68788-7804; 70518-0403; 70700-149; 71205-907; 71335-0299; 71335-1191; 71335-9609; 71713-201; 72288-123; 72559-010; 72559-014; 0781-2790; 80425-0169; 0904-6917; 55111-981; 63126-905; 65977-0044; 68981-006; 11673-018; 11673-915; 30142-593; 31722-528; 36800-121; 36800-601; 41250-401; 46122-281; 50268-657; 51407-641; 51655-893; 55111-157; 55111-159; 55319-915; 57483-840; 60760-489; 0363-6101; 63981-915; 64024-915; 64380-182; 67296-1615; 68391-103; 69842-661; 71205-613; 71335-1395; 38779-3293; 51838-100; 55111-006; 59651-310; 64239-303; 64374-100; 11673-212; 11822-1190; 21130-401; 31722-527; 37835-001; 43353-829; 46122-686; 49035-915; 51407-664; 55315-996; 55319-251; 57483-120; 57483-740
UNII KG60484QX9
Synonyms Omeprazole | Prilosec | Omeprazole Sodium | Sodium, Omeprazole | H 168-68 | H 168 68 | H 16868 | Omeprazole Magnesium | Magnesium, Omeprazole
Chemical Information
Molecular Formula C17H19N3O3S
CAS Registry Number 73590-58-6
SMILES CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood pressure inadequately controlled24.06.01.0070.000007%Not Available
Respiratory tract congestion22.02.07.003--Not Available
Lymphatic disorder01.09.01.003--Not Available
Foetor hepaticus09.01.05.006; 07.01.06.026--Not Available
Drug tolerance decreased08.06.01.024--Not Available
Protein urine present13.13.02.006--Not Available
Epigastric discomfort07.01.02.004--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Organ failure08.01.03.0410.000007%Not Available
Injection site swelling12.07.03.018; 08.02.03.0170.000023%Not Available
Colitis microscopic07.08.01.011--Not Available
Hypoaesthesia oral17.02.06.021; 07.05.05.003--Not Available
Epidermal necrosis23.03.03.035--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Hepatic enzyme increased13.03.04.028--Not Available
Breast disorder21.05.04.004--Not Available
Cardiac disorder02.11.01.0030.000007%Not Available
Connective tissue disorder10.04.04.026; 15.06.01.006--Not Available
Infestation23.11.01.002; 11.09.01.001--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.001--
Renal injury20.01.03.015; 12.01.05.0010.000007%Not Available
Ill-defined disorder08.01.03.049--Not Available
Inner ear disorder04.04.02.002--Not Available
Polyp16.02.02.005; 08.01.06.010--Not Available
Blood disorder01.05.01.004--Not Available
Adverse drug reaction08.06.01.009--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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