Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nystatin
Drug ID BADD_D01591
Description Nystatin is a polyene antifungal drug that has broad-spectrum fungicidal and fungistatic activity against a number of yeasts and fungi, most notably _Candida_ species.[L10686] It is one of the most effective antifungal agents synthesized by bacteria, in this case a strain of _Streptomyces noursei_,[L10776] and is closely related to [amphotericin B], differing only slightly in structure.[A188562] Nystatin has a greater antifungal activity than amphotericin B - parenterally administered nystatin, however, is associated with significant toxicity and is not available in a formulation appropriate for systemic use.[A188562] As it undergoes very little absorption following oral or topical administration, nystatin's efficacy is limited to the treatment/prevention of cutaneous, mucocutaneous, and gastrointestinal fungal infections.[L10686,L10728]
Indications and Usage For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species
Marketing Status Prescription; Discontinued
ATC Code A07AA02; D01AA01; G01AA01
DrugBank ID DB00646
KEGG ID D00202
MeSH ID D009761
PubChem ID 11286230
TTD Drug ID D08XAC
NDC Product Code 0574-2008; 60432-537; 68071-4293; 55154-1578; 68788-6792; 63629-2492; 13668-534; 51552-0041; 68788-7949; 71205-106; 50090-2763; 75834-235; 62991-2785; 68071-2556; 0168-0054; 70518-3284; 68308-152; 33342-481; 23155-051; 51672-1289; 55154-5788; 76003-0827; 79572-026; 50090-2854; 53734-336; 63187-422; 69315-307; 61813-701; 63629-8520; 66267-953; 51927-0095; 0832-0465; 63187-464; 0121-0868; 63629-2516; 63629-8521; 69315-306; 0121-0810; 61813-702; 63629-8697; 39822-3015; 76003-9999; 63629-2493; 16714-769; 70771-1585; 53002-8220; 50090-1740; 70771-1357; 0168-0007; 13668-595; 72578-089; 66689-008; 72189-046; 68071-2621; 0121-4810; 68094-599; 45802-048; 68788-9516; 63629-2515; 55154-4056; 63629-8698; 70166-331; 72189-278; 61813-801; 65415-1372; 66689-037; 0472-0166; 42291-651; 63187-703; 63629-8696; 63629-8695; 51672-4117; 50090-5221; 45802-059; 71205-575; 61813-802; 68382-370; 50090-5845; 63629-8350; 50090-0233; 50090-3799; 17856-0811; 33342-469; 38779-0242; 53489-400; 50090-5237; 66267-952; 50383-587; 50090-3772; 65415-1371; 63629-8694; 50090-5315; 0093-0983; 42934-400; 43386-530; 63629-8519; 63187-847
Synonyms Nystatin | Fungicidin | Mycostatin | Stamicin | Nystatin A1 | Nystatin A2 | Nystatin A3 | Nystatin G | Stamycin | Nilstat
Chemical Information
Molecular Formula C47H75NO17
CAS Registry Number 34786-70-4
SMILES CC1C=CC=CCCC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(C(CCC(CC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O )O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Diarrhoea haemorrhagic24.07.02.004; 07.02.01.002--Not Available
Eczema23.03.04.006--
Erythema multiforme23.03.01.003; 10.01.03.015--
Gastrointestinal disorder07.11.01.001--Not Available
Hypersensitivity10.01.03.003--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Pain08.01.08.004--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Stomatitis07.05.06.005--
Swelling face23.04.01.018; 10.01.05.018--Not Available
Tachycardia02.03.02.007--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
Musculoskeletal discomfort15.03.04.001--Not Available
Sensitisation08.01.05.009; 10.02.01.012--Not Available
Gastrointestinal tract irritation07.08.03.008--Not Available
The 1th Page    1    Total 1 Pages