Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nortriptyline hydrochloride
Drug ID BADD_D01589
Description Nortriptyline hydrochloride, the active metabolite of [amitriptyline], is a tricyclic antidepressant (TCA).[L11878] It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.[L11881]
Indications and Usage Primarily indicated for the relief of symptoms of depression.
Marketing Status Prescription; Discontinued
ATC Code N06AA10
DrugBank ID DB00540
KEGG ID D00816
MeSH ID D009661
PubChem ID 441358
TTD Drug ID D04WFD
NDC Product Code 51672-4004; 60760-401; 51672-4001; 70771-1612; 70710-1156; 71335-0155; 50090-0507; 67544-078; 60760-508; 43063-897; 50090-1323; 63187-809; 0591-5787; 71335-1726; 55700-501; 68071-3232; 51927-0128; 49452-4858; 17337-0534; 0406-9912; 43063-722; 46438-0049; 0121-0678; 70518-1522; 68788-7216; 55700-668; 0406-9913; 68071-3211; 63187-759; 70518-1187; 62991-2905; 70710-1155; 0591-5789; 70518-0708; 63187-153; 50090-0537; 51862-948; 61919-510; 71335-1773; 51927-2175; 0093-0810; 61919-353; 70771-1613; 68071-3109; 72189-177; 66577-025; 71205-254; 58118-4002; 71335-1552; 51862-946; 0093-0812; 68788-8158; 0406-9910; 71335-0065; 71554-011; 63187-396; 51862-947; 60760-811; 0093-0813; 70771-1615; 70710-1153; 50268-605; 51862-945; 70518-0702; 60687-293; 70518-0741; 0591-5786; 54154-007; 51862-016; 0591-5788; 71335-0426; 50268-604; 51672-4002; 68071-2327; 60687-265; 51672-4003; 61919-590; 70710-1154; 50268-603; 0406-9911; 63187-227; 63187-798; 71335-1743; 60687-281; 63187-088; 63187-715; 70771-1614; 64330-018; 68788-9830; 71335-0083; 63629-3204; 0093-0811
Synonyms Nortriptyline | Desitriptyline | Desmethylamitriptylin | Allegron | Apo-Nortriptyline | Apo Nortriptyline | Aventyl | Gen-Nortriptyline | Gen Nortriptyline | Paxtibi | Nortrilen | Nortriptyline Hydrochloride | Hydrochloride, Nortriptyline | Novo-Nortriptyline | Novo Nortriptyline | Nu-Nortriptyline | Nu Nortriptyline | Pamelor | PMS-Nortriptyline | PMS Nortriptyline | ratio-Nortriptyline | ratio Nortriptyline | Norfenazin
Chemical Information
Molecular Formula C19H22ClN
CAS Registry Number 894-71-3
SMILES CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Photosensitivity reaction23.03.09.003--
Pollakiuria20.02.02.007--
Pruritus23.03.12.001--
Purpura23.06.01.004; 24.07.06.005; 01.01.04.003--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Restlessness19.11.02.002; 17.02.05.021--
Seizure17.12.03.001--
Somnolence19.02.05.003; 17.02.04.006--
Stomatitis07.05.06.005--
Tachycardia02.03.02.007--Not Available
Testicular swelling21.13.01.003--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tongue discolouration07.14.02.006--Not Available
Tongue oedema23.04.01.009; 10.01.05.008; 07.14.02.007--Not Available
Tremor17.01.06.002--
Urinary retention20.02.02.011--
Urinary tract malformation20.08.03.002; 03.06.02.003--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Inappropriate antidiuretic hormone secretion05.03.03.001; 14.05.07.001--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.001--
Psychotic disorder19.03.01.002--
Bone marrow failure01.03.03.005--
Drug cross-reactivity10.01.01.020; 08.06.01.026--Not Available
The 3th Page    First    Pre   3    Total 3 Pages