Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Norfloxacin
Drug ID BADD_D01587
Description A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.
Indications and Usage For the treatment of urinary tract infection
Marketing Status Discontinued
ATC Code J01MA06; S01AE02
DrugBank ID DB01059
KEGG ID D00210
MeSH ID D009643
PubChem ID 4539
TTD Drug ID D0Q2PE
NDC Product Code 53104-7517
Synonyms Norfloxacin | MK-0366 | MK 0366 | MK-366 | MK 366 | MK0366 | MK366 | Noroxin | AM-0715 | AM 0715 | AM0715 | AM-715 | AM 715
Chemical Information
Molecular Formula C16H18FN3O3
CAS Registry Number 70458-96-7
SMILES CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Joint stiffness15.01.02.003--Not Available
Lacrimation increased06.08.02.004--
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Local swelling08.01.03.013--Not Available
Metabolic acidosis14.01.01.003--Not Available
Mouth ulceration07.05.06.004--Not Available
Muscle spasms15.05.03.004--
Myalgia15.05.02.001--
Myasthenia gravis17.05.04.001; 15.05.08.001; 10.04.05.001--
Myocardial infarction02.02.02.007; 24.04.04.009--
Myoclonus17.02.05.008--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Neutrophil count decreased13.01.06.010--
Nystagmus06.05.02.006; 17.02.02.006--
Oedema08.01.07.006; 14.05.06.010--Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Osteoarthritis15.01.04.001--Not Available
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005--
Photosensitivity reaction23.03.09.003--
Platelet count decreased13.01.04.001--
Polyneuropathy17.09.03.012--Not Available
Proctalgia07.03.02.001--
Proteinuria20.02.01.011--
Prothrombin time prolonged13.01.02.012--Not Available
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