Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Norepinephrine
Drug ID BADD_D01583
Description Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Indications and Usage Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
Marketing Status Prescription; Discontinued
ATC Code C01CA03
DrugBank ID DB00368
KEGG ID D00076
MeSH ID D009638
PubChem ID 439260
TTD Drug ID D07MOX
NDC Product Code 44911-0282; 43857-0161; 43742-0951; 43742-1319; 43857-0260; 63083-1530
Synonyms Norepinephrine | Levonorepinephrine | Noradrenaline | Levarterenol | Levophed | Levophed Bitartrate | Noradrénaline tartrate renaudin | Norepinephrine Bitartrate | Norepinephrine l-Tartrate (1:1) | Noradrenaline Bitartrate | Norepinephrine d-Tartrate (1:1) | Norepinephrin d-Tartrate (1:1) | Norepinephrine Hydrochloride | Norepinephrine Hydrochloride, (+)-Isomer | Norepinephrine Hydrochloride, (+,-)-Isomer | Norepinephrine l-Tartrate (1:1), (+,-)-Isomer | Norepinephrine l-Tartrate (1:1), Monohydrate | Norepinephrine l-Tartrate (1:1), Monohydrate, (+)-Isomer | Norepinephrine l-Tartrate (1:2) | Norepinephrine l-Tartrate, (+)-Isomer | Norepinephrine, (+)-Isomer | Norepinephrine, (+,-)-Isomer | Arterenol | Levonor
Chemical Information
Molecular Formula C8H11NO3
CAS Registry Number 51-41-2
SMILES C1=CC(=C(C=C1C(CN)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Poor peripheral circulation24.04.03.0130.000371%Not Available
Pulmonary oedema22.01.03.003; 02.05.02.0030.000556%
Tachycardia02.03.02.0070.000927%Not Available
Vasoconstriction23.06.05.007; 24.04.03.0080.000371%Not Available
Vomiting07.01.07.003--
Haemorrhage24.07.01.0020.000742%Not Available
Venous occlusion24.04.02.0090.000371%Not Available
Stress cardiomyopathy24.04.04.026; 02.04.01.0120.001298%Not Available
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