Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Norepinephrine
Drug ID BADD_D01583
Description Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Indications and Usage Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
Marketing Status approved
ATC Code C01CA03
DrugBank ID DB00368
KEGG ID D00076
MeSH ID D009638
PubChem ID 439260
TTD Drug ID D07MOX
NDC Product Code 43742-1319; 63083-1530; 43857-0161; 43857-0260
UNII X4W3ENH1CV
Synonyms Norepinephrine | Levonorepinephrine | Noradrenaline | Levarterenol | Levophed | Levophed Bitartrate | Noradrénaline tartrate renaudin | Norepinephrine Bitartrate | Norepinephrine l-Tartrate (1:1) | Noradrenaline Bitartrate | Norepinephrine d-Tartrate (1:1) | Norepinephrin d-Tartrate (1:1) | Norepinephrine Hydrochloride | Norepinephrine Hydrochloride, (+)-Isomer | Norepinephrine Hydrochloride, (+,-)-Isomer | Norepinephrine l-Tartrate (1:1), (+,-)-Isomer | Norepinephrine l-Tartrate (1:1), Monohydrate | Norepinephrine l-Tartrate (1:1), Monohydrate, (+)-Isomer | Norepinephrine l-Tartrate (1:2) | Norepinephrine l-Tartrate, (+)-Isomer | Norepinephrine, (+)-Isomer | Norepinephrine, (+,-)-Isomer | Arterenol | Levonor
Chemical Information
Molecular Formula C8H11NO3
CAS Registry Number 51-41-2
SMILES C1=CC(=C(C=C1C(CN)O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Lactic acidosis14.01.01.002--Not Available
Myocardial ischaemia24.04.04.010; 02.02.02.0080.000085%Not Available
Myocarditis02.04.03.0010.000085%
Necrosis24.04.02.006; 08.03.03.0010.000085%Not Available
Necrosis ischaemic24.04.02.0180.000085%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.000085%
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Peripheral ischaemia24.04.03.0020.000211%
Photophobia17.17.02.006; 06.01.01.004--
Poor peripheral circulation24.04.03.0130.000085%Not Available
Presyncope02.11.04.013; 24.06.02.010; 17.02.05.0090.000085%
Pulmonary oedema22.01.03.003; 02.05.02.0030.000127%
Renal failure20.01.03.0050.000127%Not Available
Supraventricular tachycardia02.03.03.0120.000228%
Swelling08.01.03.0150.000085%Not Available
Tachycardia02.03.02.0070.000254%Not Available
Thrombosis24.01.01.0060.000085%Not Available
Vasoconstriction24.04.03.008; 23.06.05.0070.000169%Not Available
Ventricular tachycardia02.03.04.0100.000085%
Vomiting07.01.07.003--
Dry gangrene24.04.03.018; 23.06.06.0030.000254%Not Available
Haemodynamic instability24.03.02.0060.000372%Not Available
Haemorrhage24.07.01.0020.000127%Not Available
Venous occlusion24.04.02.0090.000085%Not Available
Infusion site extravasation12.07.05.008; 08.02.05.0070.000127%
Posterior reversible encephalopathy syndrome17.13.02.0070.000085%
Mitral valve stenosis02.07.01.0090.000085%Not Available
Communication disorder19.19.01.0080.000288%Not Available
Stress cardiomyopathy24.04.04.026; 02.04.01.0120.000592%Not Available
Hyperdynamic left ventricle02.11.04.0100.000085%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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