| Drug Name |
Nitrofurantoin |
| Drug ID |
BADD_D01576 |
| Description |
Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections.[L6856,L6859,L6862] Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein.[A179824] This drug is more resistant to the development of bacterial resistance because it acts on many targets at once.[A179824] Nitrofurantoin is a second line treatment to [trimethoprim]/[sulfamethoxazole].[A179830]
Nitrofurantoin was granted FDA approval on 6 February 1953.[L6895] |
| Indications and Usage |
May be used as an alternative in the treatment of urinary tract infections. May be used by females pericoitally for prophylaxis against recurrent cystitis related to coitus. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
J01XE01 |
| DrugBank ID |
DB00698
|
| KEGG ID |
D00439
|
| MeSH ID |
D009582
|
| PubChem ID |
6604200
|
| TTD Drug ID |
D0R0BX
|
| NDC Product Code |
62332-389; 0591-3686; 60687-472; 48087-0009; 61919-458; 43386-450; 16571-740; 63629-2464; 71205-365; 0591-3684; 60687-483; 13811-719; 40032-450; 0115-2024; 65162-689; 71335-1374; 48087-0148; 0591-3685; 51927-5024; 0472-1992; 62332-390; 68001-423; 62332-391; 71052-240; 46708-390; 48087-0029; 68071-5050; 70199-006; 46708-389; 71335-0878; 48087-0097; 48087-0081; 46708-391; 72189-179; 71205-370; 68071-2281; 70408-239; 48087-0147; 60862-006; 0115-2023; 48087-0146 |
| Synonyms |
Nitrofurantoin | Furadoine | Nitrofurantoin, Monohydrate | Furantoin | Macrodantin | Nitrofurantoin Sodium Salt | Furadantin | Furadantine | Furadonine |
