Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nitric oxide
Drug ID BADD_D01574
Description Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power plants. Nitric oxide (NO) should not be confused with nitrous oxide (N2O), a general anaesthetic, or with nitrogen dioxide (NO2) which is another poisonous air pollutant. The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity. It reacts with the ozone in air to form nitrogen dioxide, signalled by the appearance of the reddish-brown color.
Indications and Usage For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure
Marketing Status Prescription; Discontinued
ATC Code R07AX01
DrugBank ID DB00435
KEGG ID D00074
MeSH ID D009569
PubChem ID 145068
TTD Drug ID D0A5FM
NDC Product Code 72385-001; 80519-301; 64693-002
Synonyms Nitric Oxide | Oxide, Nitric | Nitrogen Monoxide | Monoxide, Nitrogen | Nitric Oxide, Endothelium-Derived | Endothelium-Derived Nitric Oxide | Nitric Oxide, Endothelium Derived | Endogenous Nitrate Vasodilator | Nitrate Vasodilator, Endogenous | Vasodilator, Endogenous Nitrate | Mononitrogen Monoxide | Monoxide, Mononitrogen
Chemical Information
Molecular Formula NO
CAS Registry Number 10102-43-9
SMILES [N]=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ApoptosisGolgi SNAP receptor complex member 1O95249Not AvailableNot Available
ApoptosisNoc7E5DUJ3Not AvailableNot Available
ApoptosisNADP-dependent oxidoreductase 3W4JPE0Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaemia01.03.02.001-
Aortic dissection24.02.03.002-Not Available
Atelectasis22.01.02.001--
Blood pressure decreased13.14.03.002-Not Available
Bradycardia02.03.02.002-Not Available
Cardiac arrest02.03.04.001-
Cardiac failure02.05.01.001-
Cardio-respiratory arrest22.02.06.007; 02.03.04.002-Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003-Not Available
Cerebral infarction17.08.01.004; 24.04.06.002--Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Convulsion neonatal18.04.04.003; 17.12.03.017-Not Available
Death08.04.01.001-
Death neonatal18.04.01.002; 08.04.01.002-
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Dry mouth07.06.01.002-
Dry throat22.02.05.004; 07.06.01.005--Not Available
Dyspnoea22.02.01.004; 02.01.03.002--
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Haemoglobin13.01.05.018--Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.008--
Headache17.14.01.001--
Heart rate decreased13.14.04.001-Not Available
Hypotension24.06.03.002-
Hypoxia22.02.02.003-
Influenza11.05.03.001; 22.07.02.001-Not Available
Intracranial pressure increased17.07.02.002-Not Available
Intraventricular haemorrhage24.07.04.008; 17.08.01.017-Not Available
Lung disorder22.02.07.001-Not Available
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