Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nicotine
Drug ID BADD_D01564
Description Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Indications and Usage For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Marketing Status approved
ATC Code N07BA01
DrugBank ID DB00184
KEGG ID D03365
MeSH ID D009538
PubChem ID 89594
TTD Drug ID D0T8GD
NDC Product Code 17205-601; 58316-010; 11673-195; 11673-879; 37808-900; 37808-948; 43598-447; 59450-003; 59779-443; 70000-0115; 0536-1107; 70677-0030; 52922-001; 58316-009; 75877-0002; 11822-3627; 11822-4975; 21130-820; 37808-533; 37808-658; 43598-448; 49035-195; 55910-313; 66715-9802; 66715-9805; 66715-9806; 70000-0114; 28663-009; 58316-006; 11673-727; 11673-881; 37808-682; 0135-0196; 37808-711; 37808-739; 49035-196; 53329-192; 59450-002; 60429-443; 60429-445; 62011-0351; 63868-734; 70677-0032; 60429-444; 0363-0455; 0363-0457; 66715-9804; 68016-288; 28663-010; 58316-011; 11822-4973; 37808-753; 43598-446; 0009-5401; 50090-1148; 53329-193; 68016-289; 0536-1108; 58316-008; 29485-5271; 50090-2860; 63981-124; 66715-9803; 68196-194; 0536-1106; 61252-3005; 50090-1697; 59450-001; 63981-190; 70677-0031; 0135-0194; 0135-0195; 49035-782; 49348-788; 50090-2837; 59779-445; 62011-0350; 63868-735; 66715-9801; 68016-290; 69842-828; 50392-101; 55742-003; 11673-971; 11822-4974; 37808-707; 37808-849; 50090-6383; 55741-449; 59779-448; 0363-0451; 62011-0349; 81870-001; 11673-269; 11673-424; 21130-269; 43598-445; 53329-191; 69842-605; 70000-0113; 58316-007; 11673-194; 11673-196; 29485-5270; 37808-383; 37808-911; 49035-194; 0009-5400
UNII 6M3C89ZY6R
Synonyms Nicotine | Nicotine Bitartrate | Nicotine Tartrate
Chemical Information
Molecular Formula C10H14N2
CAS Registry Number 54-11-5; 22083-74-5
SMILES CN1CCCC1C2=CN=CC=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Feeling abnormal08.01.09.0140.013602%Not Available
Feeling cold08.01.09.008--Not Available
Flat affect19.04.01.004--Not Available
Flatulence07.01.04.0020.001692%
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Galactorrhoea21.05.02.002; 05.03.04.002--Not Available
Gastric ulcer07.04.03.002--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Generalised oedema14.05.06.007; 08.01.07.004--
Gestational diabetes18.02.04.001; 14.06.01.008; 05.06.01.0080.001567%Not Available
Gingival bleeding24.07.02.010; 07.09.07.001--Not Available
Gingival disorder07.09.13.0040.003197%Not Available
Gingival pain07.09.13.010--
Gingival swelling07.09.13.013--Not Available
Gingivitis11.01.04.013; 07.09.10.002--
Glossitis07.14.01.0010.001379%Not Available
Glossodynia07.14.02.0010.002758%Not Available
Goitre14.11.01.008; 05.02.01.0010.000627%Not Available
Haematemesis07.12.02.002; 24.07.02.011--Not Available
Haemoptysis22.02.03.004; 02.11.04.009; 24.07.01.006--Not Available
Haemorrhage in pregnancy18.02.01.003; 24.07.03.0150.000940%Not Available
Haemorrhage subcutaneous24.07.06.010; 23.06.07.0020.001254%Not Available
Hallucination19.10.04.0030.002194%
Hallucination, auditory19.10.04.004--Not Available
Hallucination, visual19.10.04.007--Not Available
Headache17.14.01.001--
Hepatic failure09.01.03.0020.000940%
Hiatus hernia22.09.02.004; 07.16.01.0010.000627%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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