ADReCS

Pharmaceutical Information

Drug Name	Nicotine
Drug ID	BADD_D01564
Description	Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Indications and Usage	For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Marketing Status	approved
ATC Code	N07BA01
DrugBank ID	DB00184
KEGG ID	D03365
MeSH ID	D009538
PubChem ID	89594
TTD Drug ID	D0T8GD
NDC Product Code	17205-601; 58316-010; 11673-195; 11673-879; 37808-900; 37808-948; 43598-447; 59450-003; 59779-443; 70000-0115; 0536-1107; 70677-0030; 52922-001; 58316-009; 75877-0002; 11822-3627; 11822-4975; 21130-820; 37808-533; 37808-658; 43598-448; 49035-195; 55910-313; 66715-9802; 66715-9805; 66715-9806; 70000-0114; 28663-009; 58316-006; 11673-727; 11673-881; 37808-682; 0135-0196; 37808-711; 37808-739; 49035-196; 53329-192; 59450-002; 60429-443; 60429-445; 62011-0351; 63868-734; 70677-0032; 60429-444; 0363-0455; 0363-0457; 66715-9804; 68016-288; 28663-010; 58316-011; 11822-4973; 37808-753; 43598-446; 0009-5401; 50090-1148; 53329-193; 68016-289; 0536-1108; 58316-008; 29485-5271; 50090-2860; 63981-124; 66715-9803; 68196-194; 0536-1106; 61252-3005; 50090-1697; 59450-001; 63981-190; 70677-0031; 0135-0194; 0135-0195; 49035-782; 49348-788; 50090-2837; 59779-445; 62011-0350; 63868-735; 66715-9801; 68016-290; 69842-828; 50392-101; 55742-003; 11673-971; 11822-4974; 37808-707; 37808-849; 50090-6383; 55741-449; 59779-448; 0363-0451; 62011-0349; 81870-001; 11673-269; 11673-424; 21130-269; 43598-445; 53329-191; 69842-605; 70000-0113; 58316-007; 11673-194; 11673-196; 29485-5270; 37808-383; 37808-911; 49035-194; 0009-5400
UNII	6M3C89ZY6R
Synonyms	Nicotine \| Nicotine Bitartrate \| Nicotine Tartrate

Chemical Information

Molecular Formula	C10H14N2
CAS Registry Number	54-11-5; 22083-74-5
SMILES	CN1CCCC1C2=CN=CC=C2
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Skin irritation	23.03.04.009	0.007334%		Not Available
Skin reaction	23.03.03.013; 10.01.03.019	0.001379%		Not Available
Sleep disorder	19.02.04.001	0.002946%		Not Available
Sneezing	22.12.03.024	0.003824%
Somnolence	19.02.05.003; 17.02.04.006	-	-
Stillbirth	08.04.01.006; 18.01.02.002	0.001254%		Not Available
Stomatitis	07.05.06.005	0.004012%
Stress	19.06.02.004	0.002319%		Not Available
Stupor	19.02.05.004; 17.02.04.007	-	-	Not Available
Suicidal ideation	19.12.01.003	0.003260%
Swelling	08.01.03.015	0.004889%		Not Available
Swelling face	23.04.01.018; 10.01.05.018; 08.01.03.100	0.002006%		Not Available
Swollen tongue	10.01.05.015; 23.04.01.014; 07.14.02.003	0.001379%		Not Available
Syncope	24.06.02.012; 17.02.04.008; 02.11.04.015	0.002821%
Synovial cyst	16.18.01.004; 15.04.02.002	0.001254%		Not Available
Tachycardia	02.03.02.007	0.003134%		Not Available
Tachypnoea	22.02.01.014	0.000940%		Not Available
Tenderness	08.01.08.005	-	-	Not Available
Tendonitis	15.07.01.003; 12.01.07.007	0.000627%		Not Available
Tension	19.06.02.005	0.000627%		Not Available
Therapeutic response decreased	08.06.01.016	0.001379%		Not Available
Therapeutic response unexpected	08.06.01.001	0.001379%		Not Available
Throat irritation	22.12.03.029; 07.05.05.037	0.005955%		Not Available
Throat tightness	22.12.03.031; 19.01.02.005	0.002445%		Not Available
Thyroid disorder	05.02.01.002	-	-	Not Available
Tongue coated	07.14.02.011	-	-	Not Available
Tongue disorder	07.14.01.002	-	-	Not Available
Tongue neoplasm malignant stage unspecified	16.13.07.003; 07.21.07.003	0.001254%		Not Available
Tongue oedema	23.04.01.009; 10.01.05.008; 07.14.02.007	-	-	Not Available
Tooth discolouration	07.09.02.001	-	-

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